G
Greg J. Duncan
Researcher at Oregon Health & Science University
Publications - 17
Citations - 1317
Greg J. Duncan is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Remyelination & Oligodendrocyte. The author has an hindex of 12, co-authored 15 publications receiving 876 citations. Previous affiliations of Greg J. Duncan include University of British Columbia.
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Journal ArticleDOI
Cell transplantation therapy for spinal cord injury
TL;DR: A better understanding of the mechanisms whereby these cells promote functional improvements will be important to make cell transplantation a viable clinical option and may lead to the development of more targeted therapies.
Journal ArticleDOI
Remyelination after spinal cord injury: is it a target for repair?
Jason R. Plemel,Michael B. Keough,Greg J. Duncan,Joseph S. Sparling,V. Wee Yong,Peter K. Stys,Wolfram Tetzlaff +6 more
TL;DR: This review discusses strategies to promote remyelination after SCI largely limited to cellular transplantation as well as new, and largely untested, modes of therapy that aim to coax endogenous cells residing adjacent to the injury site to differentiate in order to replace lost myelin.
Journal ArticleDOI
A graded forceps crush spinal cord injury model in mice
Jason R. Plemel,Greg J. Duncan,Kai-Wei K. Chen,Casey P. Shannon,Sophia Park,Joseph S. Sparling,Wolfram Tetzlaff +6 more
TL;DR: Evidence is provided that the graded forceps crush model for SCI in mice is an attractive alternative for the study of SCI and related therapeutic interventions because of its demonstrated consistency, ease of use, low cost, and clinical relevance.
Journal ArticleDOI
Myelinogenic Plasticity of Oligodendrocyte Precursor Cells Following Spinal Cord Contusion Injury
Peggy Assinck,Greg J. Duncan,Jason R. Plemel,Michael J. Lee,Jo Anne Stratton,Sohrab B. Manesh,Jie Liu,Leanne M. Ramer,Shin H. Kang,Dwight E. Bergles,Jeff Biernaskie,Jeff Biernaskie,Wolfram Tetzlaff +12 more
TL;DR: Findings reveal that PDGFRα+ cells perform diverse roles in CNS repair, as multipotential progenitors that generate both classes of myelinating cells, raising the possibility that CNS precursors could be manipulated to repair myelin in lieu of glial transplantation.
Journal ArticleDOI
Myelin regulatory factor drives remyelination in multiple sclerosis.
Greg J. Duncan,Jason R. Plemel,Peggy Assinck,Sohrab B. Manesh,Fraser G. W. Muir,Ryan Hirata,Matan Berson,Jie Liu,Michael Wegner,Ben Emery,Ben Emery,G. R. Wayne Moore,G. R. Wayne Moore,Wolfram Tetzlaff +13 more
TL;DR: It is shown, for the first time, that chronic lesions lack oligodendrocytes that express this necessary transcription factor for remyelination and supports the notion that a failure to fully differentiate underlies remYelination failure.