J
Jo Anne Stratton
Researcher at Montreal Neurological Institute and Hospital
Publications - 39
Citations - 1454
Jo Anne Stratton is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 16, co-authored 28 publications receiving 831 citations. Previous affiliations of Jo Anne Stratton include Florey Institute of Neuroscience and Mental Health & University of Melbourne.
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Journal ArticleDOI
Adult Neural Precursor Cells from the Subventricular Zone Contribute Significantly to Oligodendrocyte Regeneration and Remyelination
Yao Lulu Xing,Philipp T. Röth,Jo Anne Stratton,Bernard H.A. Chuang,Jill Danne,Sarah Ellis,Sze Woei Ng,Trevor J. Kilpatrick,Tobias D. Merson +8 more
TL;DR: A major distinct role is defined for NPCs in remyelination, identifying them as a key target for enhancing myelin repair in demyelinating diseases.
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Single-Cell Transcriptomics and Fate Mapping of Ependymal Cells Reveals an Absence of Neural Stem Cell Function
Prajay Shah,Jo Anne Stratton,Jo Anne Stratton,Morgan G. Stykel,Sepideh Abbasi,Sandeep Sharma,Kyle A. Mayr,Kathrin Koblinger,Patrick J. Whelan,Jeff Biernaskie,Jeff Biernaskie +10 more
TL;DR: A transgenic system that allows for targeted labeling of ependymal cells within the ventricular-subventricular zone and fundamental insights into the molecular signature of the V-SVZ niche are described.
Journal ArticleDOI
Macrophages Regulate Schwann Cell Maturation after Nerve Injury.
Jo Anne Stratton,Alexandra Holmes,Nicole L. Rosin,Sarthak Sinha,Mohit Vohra,Nicole E. Burma,Tuan Trang,Rajiv Midha,Jeff Biernaskie,Jeff Biernaskie +9 more
TL;DR: It is demonstrated that after injury, including in humans, macrophages function to clear debris and persist within the nerve microenvironment and highlight a molecular mechanism by which this occurs.
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Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion
Jason R. Plemel,Jason R. Plemel,Jo Anne Stratton,Nathan J. Michaels,Khalil S. Rawji,Eric Zhang,Sarthak Sinha,Charbel S. Baaklini,Yifei Dong,Madelene Ho,Kevin Thorburn,Timothy N. Friedman,Sana Jawad,Claudia Silva,Andrew V. Caprariello,Vahid Hoghooghi,Julie Yue,Arzina Jaffer,Kelly Lee,Bradley J. Kerr,Raj Midha,Peter K. Stys,Jeff Biernaskie,V. Wee Yong +23 more
TL;DR: The restriction of peripheral inflammation by microglia may be a previously unidentified mechanism by which the central nervous system maintains its “immune privileged” status.
Journal ArticleDOI
Targeted Ablation of Oligodendrocytes Induces Axonal Pathology Independent of Overt Demyelination
Laura Jane Oluich,Jo Anne Stratton,Yao Lulu Xing,Sze Woei Ng,Holly S. Cate,Pankaj Sah,François Windels,Trevor J. Kilpatrick,Tobias D. Merson,Tobias D. Merson +9 more
TL;DR: It is shown that a death signal initiated within oligodendrocytes results in subcellular changes and loss of key symbiotic interactions between the oligodends and the axons it ensheaths, which produces profound functional consequences that occur before the removal of the myelin membrane, i.e., in the absence of demyelination.