D
Dwight E. Bergles
Researcher at Johns Hopkins University
Publications - 148
Citations - 18598
Dwight E. Bergles is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Oligodendrocyte & Glutamate receptor. The author has an hindex of 62, co-authored 130 publications receiving 15015 citations. Previous affiliations of Dwight E. Bergles include University of Oslo & Discovery Institute.
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Journal ArticleDOI
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Jeffrey D. Rothstein,Sarjubhai Patel,Melissa R. Regan,Christine Haenggeli,Yanhua H. Huang,Dwight E. Bergles,Lin Jin,Margaret Dykes Hoberg,Svetlana Vidensky,Dorothy S. Chung,Shuy Vang Toan,Lucie I. Bruijn,Zao-Zhong Su,Pankaj Gupta,Paul B. Fisher +14 more
TL;DR: Using a blinded screen of 1,040 FDA-approved drugs and nutritionals, it is discovered that many β-lactam antibiotics are potent stimulators of GLT1 expression, and this action appears to be mediated through increased transcription of theGLT1 gene.
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Glutamatergic synapses on oligodendrocyte precursor cells in the hippocampus.
TL;DR: It is reported that stimulation of excitatory axons in the hippocampus elicits inward currents in OPCs that are mediated by AMPA receptors, and electron microscopic analysis revealed that vesicle-filled axon terminals make synaptic junctions with the processes of O PCs in both the young and adult hippocampus.
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Reactive astrocyte nomenclature, definitions, and future directions
Carole Escartin,Elena Galea,Andras Lakatos,James P. O'Callaghan,Gabor C. Petzold,Gabor C. Petzold,Alberto Serrano-Pozo,Christian Steinhäuser,Andrea Volterra,Giorgio Carmignoto,Giorgio Carmignoto,Amit Agarwal,Nicola J. Allen,Alfonso Araque,Luis Barbeito,Ari Barzilai,Dwight E. Bergles,Gilles Bonvento,Arthur M. Butt,Wei Ting Chen,Martine Cohen-Salmon,Colm Cunningham,Benjamin Deneen,Bart De Strooper,Bart De Strooper,Blanca Diaz-Castro,Cinthia Farina,Marc R. Freeman,Vittorio Gallo,James E. Goldman,Steven A. Goldman,Steven A. Goldman,Magdalena Götz,Antonia Gutierrez,Philip G. Haydon,Dieter Henrik Heiland,Elly M. Hol,Matthew Holt,Masamitsu Iino,Ksenia V. Kastanenka,Helmut Kettenmann,Baljit S. Khakh,Schuichi Koizumi,C. Justin Lee,Shane A. Liddelow,Brian A. MacVicar,Pierre J. Magistretti,Pierre J. Magistretti,Albee Messing,Anusha Mishra,Anna V. Molofsky,Keith K. Murai,Christopher M. Norris,Seiji Okada,Stéphane H. R. Oliet,João Filipe Oliveira,João Filipe Oliveira,Aude Panatier,Vladimir Parpura,Marcela Pekna,Milos Pekny,Luc Pellerin,Gertrudis Perea,Beatriz G. Pérez-Nievas,Frank W. Pfrieger,Kira E. Poskanzer,Francisco J. Quintana,Richard M. Ransohoff,Miriam Riquelme-Perez,Stefanie Robel,Christine R. Rose,Jeffrey D. Rothstein,Nathalie Rouach,David H. Rowitch,Alexey Semyanov,Alexey Semyanov,Swetlana Sirko,Harald Sontheimer,Raymond A. Swanson,Javier Vitorica,Ina B. Wanner,Levi B. Wood,Jia Qian Wu,Binhai Zheng,Eduardo R. Zimmer,Robert Zorec,Michael V. Sofroniew,Alexei Verkhratsky,Alexei Verkhratsky +88 more
TL;DR: In this article, the authors point out the shortcomings of binary divisions of reactive astrocytes into good-vs-bad, neurotoxic vs-neuroprotective or A1-vs.A2.
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NG2+ CNS Glial Progenitors Remain Committed to the Oligodendrocyte Lineage in Postnatal Life and following Neurodegeneration
TL;DR: The results indicate that NG2+ cells in the normal CNS are oligodendrocyte precursors with restricted lineage potential and that cell loss and gliosis are not sufficient to alter the lineage potential of these progenitors.
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Oligodendrocyte progenitors balance growth with self-repulsion to achieve homeostasis in the adult brain.
TL;DR: Homeostatic control of NG2+ cell density through a balance of active growth and self-repulsion ensures that these progenitors are available to replace oligodendrocytes and participate in tissue repair.