Gregory Hughes

TL;DR: An efficient biocatalytic process to replace a recently implemented rhodium-catalyzed asymmetric enamine hydrogenation for the large-scale manufacture of the antidiabetic compound sitagliptin is reported, underscoring the maturation of bioc atalysis to enable efficient, economical, and environmentally benign processes for the manufacture of pharmaceuticals.

TL;DR: An in vitro biocatalytic cascade synthesis of the investigational HIV treatment islatravir is reported, requiring fewer than half the number of steps of the previously reported routes.

TL;DR: The medicinal chemistry subgroup of the American Chemical Society's Green Chemistry Institute Pharmaceutical Roundtable (ACS GCI PR) offers a perspective on the current state of environmentally sustainable practices in medicinal chemistry with the aim of sharing best practices more widely and highlighting some potential future developments.

TL;DR: General methods for the highly site-selective Suzuki monocoupling of 3,5-dichloropyridazines have been discovered, enabling the rapid construction of diverse arrays of diarylpyradazines in a modular fashion.

TL;DR: The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reduction enzymes, host cells capable of expressing the engineered reductases, and methods of using these engineered PU with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds as mentioned in this paper.