M
Marian C. Bryan
Researcher at Genentech
Publications - 56
Citations - 3711
Marian C. Bryan is an academic researcher from Genentech. The author has contributed to research in topics: Pyrazolopyrimidine & T790M. The author has an hindex of 22, co-authored 56 publications receiving 3387 citations. Previous affiliations of Marian C. Bryan include Amgen & California Institute of Technology.
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Journal ArticleDOI
Printed covalent glycan array for ligand profiling of diverse glycan binding proteins
Ola Blixt,Steve Head,Tony S. Mondala,Christopher N. Scanlan,Margaret E. Huflejt,Richard Alvarez,Marian C. Bryan,Fabio Fazio,Daniel A. Calarese,James Stevens,Nahid Razi,D.J. Stevens,John J. Skehel,Irma van Die,Dennis R. Burton,Ian A. Wilson,Richard D. Cummings,Nicolai V. Bovin,Chi-Huey Wong,James C. Paulson +19 more
TL;DR: A glycan microarray constructed by using standard robotic microarray printing technology to couple amine functionalized glycans to an amino-reactive glass slide has remarkable utility for profiling the specificity of a diverse range of glycan binding proteins.
Journal ArticleDOI
Synthesis of sugar arrays in microtiter plate.
TL;DR: 1,3-Dipolar cycloadditions between azides and alkynes were exploited to attach oligosaccharides to a C(14) hydrocarbon chain that noncovalently binds to the microtiter well surface to achieve biotransformation of beta-galactosyllipid 5.
Journal ArticleDOI
Probing the dynamics of O -GlcNAc glycosylation in the brain using quantitative proteomics
Nelly Khidekel,Scott B. Ficarro,Peter M. Clark,Marian C. Bryan,Danielle L. Swaney,Jessica E. Rexach,Yi E. Sun,Joshua J. Coon,Eric C. Peters,Linda C. Hsieh-Wilson +9 more
TL;DR: The method is termed quantitative isotopic and chemoenzymatic tagging (QUIC-Tag), and it is suggested that O-GlcNAc glycosylation occurs reversibly in neurons and, akin to phosphorylation, may have important roles in mediating the communication between neurons.
Journal ArticleDOI
Key Green Chemistry research areas from a pharmaceutical manufacturers’ perspective revisited
Marian C. Bryan,Peter J. Dunn,David Entwistle,Fabrice Gallou,Stefan G. Koenig,John D. Hayler,Matthew R. Hickey,Shaun Hughes,Michael E. Kopach,Gerard Moine,Paul G. Richardson,Frank Roschangar,Alan Steven,Franz J. Weiberth +13 more
TL;DR: In 2007, the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable assembled a list of key green chemistry research areas to both identify transformations that would benefit from improvements in process greenness and to encourage academic research to this end as mentioned in this paper.
Journal ArticleDOI
Covalent display of oligosaccharide arrays in microtiter plates.
Marian C. Bryan,Fabio Fazio,Hing-Ken Lee,Cheng-Yuan Huang,Aileen Y. Chang,Michael D. Best,Daniel A. Calarese,Ola Blixt,James C. Paulson,Dennis R. Burton,Ian A. Wilson,Chi-Huey Wong +11 more
TL;DR: A covalent array for the display of complex oligosaccharides in microtiter plates has been developed and was used to probe the multivalent interaction of 2G12 with an optimal epitope (Kd 0.1 muM).