Guan-Lin Sun

TL;DR: As2O3 treatment is an effective and relatively safe drug in APL patients refractory to ATRA and conventional chemotherapy, and Pharmacokinetic studies showed that after a peak level of 5.54 micromol/L, plasma arsenic was rapidly eliminated, and the continuous administration of As2O2 did not alter its pharmacokinetic behaviors.

TL;DR: In this paper, As2O3 was shown to trigger NB4 cell apoptosis at micromolar concentration, as proved by morphology, histogramic related nuclear DNA contents, and DNA gel eletrophoresis.

TL;DR: Analysis of cell proliferation and clonogenic ability showed that As( 4)S(4) and imatinib exerted synergistic effects on both K562 cells and fresh CML cells, and in vitro data strongly suggest a potential clinical application ofImatinib and As(4]S(3) combination on CML.

TL;DR: Preliminary results from studies in patients with primary hepatocellular and gallbladder tumors indicate that ATO may also prove active against some solid tumors, and the mechanism of action of ATO suggests it may be active against other malignancies.