Z
Zhu Chen
Researcher at Shanghai Jiao Tong University
Publications - 326
Citations - 31365
Zhu Chen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Acute promyelocytic leukemia & Leukemia. The author has an hindex of 80, co-authored 312 publications receiving 28252 citations. Previous affiliations of Zhu Chen include Ruijin Hospital & National Foundation for Cancer Research.
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Journal ArticleDOI
Effectiveness of convalescent plasma therapy in severe COVID-19 patients.
Kai Duan,Bende Liu,Li Cesheng,Huajun Zhang,Ting Yu,Jieming Qu,Min Zhou,Li Chen,Shengli Meng,Hu Yong,Cheng Peng,Mingchao Yuan,Jinyan Huang,Zejun Wang,Jianhong Yu,Xiaoxiao Gao,Dan Wang,Xiaoqi Yu,Li Li,Jiayou Zhang,Xiao Wu,Bei Li,Yanping Xu,Wei Chen,Peng Yan,Yeqin Hu,Lin Lianzhen,Xuefei Liu,Shihe Huang,Zhou Zhijun,Lianghao Zhang,Yue Wang,Zhang Zhi,Kun Deng,Zhiwu Xia,Gong Qin,Wei Zhang,Xiaobei Zheng,Ying Liu,Huichuan Yang,Dongbo Zhou,Ding Yu,Jifeng Hou,Zhengli Shi,Sai-Juan Chen,Zhu Chen,Xinxin Zhang,Xiaoming Yang +47 more
TL;DR: CP therapy was well tolerated and could potentially improve the clinical outcomes through neutralizing viremia in severe COVID-19 cases and the optimal dose and time point, as well as the clinical benefit of CP therapy, needs further investigation in larger well-controlled trials.
Journal ArticleDOI
Acute promyelocytic leukemia: from highly fatal to highly curable.
Zhen-Yi Wang,Zhu Chen +1 more
TL;DR: The history of introduction of ATRA and ATO into clinical use and the mechanistic studies in understanding this model of cancer targeted therapy are reviewed.
Journal ArticleDOI
A Human Genome Diversity Cell Line Panel
Howard M. Cann,Claudia de Toma,Lucien Cazes,Marie Fernande Legrand,Valérie Morel,Laurence Piouffre,J. G. Bodmer,Walter F. Bodmer,Batsheva Bonne-Tamir,Anne Cambon-Thomsen,Zhu Chen,Jiayou Chu,Carlo Carcassi,Licinio Contu,Ruofu Du,Laurent Excoffier,G. B. Ferrara,Jonathan S. Friedlaender,Helena Groot,David Gurwitz,Trefor Jenkins,Rene J. Herrera,Xiaoyi Huang,Judith R. Kidd,Kenneth K. Kidd,André Langaney,Alice A. Lin,S. Qasim Mehdi,Peter Parham,Alberto Piazza,Maria Pia Pistillo,Yaping Qian,Qunfang Shu,Jiujin Xu,Shi-Yao Zhu,James L. Weber,Henry T. Greely,Marcus W. Feldman,Gilles Thomas,Jean Dausset,Luigi Luca Cavalli-Sforza +40 more
TL;DR: A resource of 1064 cultured lymphoblastoid cell lines from individuals in different world populations and corresponding milligram quantities of DNA is deposited at the Foundation Jean Dausset (CEPH) in Paris.
Journal ArticleDOI
In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins
Guo-Qiang Chen,Jun Zhu,Xue-Geng Shi,Jian-Hua Ni,Hao-Jie Zhong,Gui-Ying Si,Xiao-Long Jin,Wei Tang,Xiu-Shong Li,Shu-Ming Xong,Zhi-Xiang Shen,Guan-Lin Sun,Jun Ma,Peng Zhang,Ting-Dong Zhang,Claude Gazin,Tomoki Naoe,Sai-Juan Chen,Zhen-Yi Wang,Zhu Chen +19 more
TL;DR: In this paper, As2O3 was shown to trigger NB4 cell apoptosis at micromolar concentration, as proved by morphology, histogramic related nuclear DNA contents, and DNA gel eletrophoresis.
Journal ArticleDOI
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells
Guo-Qiang Chen,Xue-Geng Shi,Wei Tang,Shu-Min Xiong,Jun Zhu,Xun Cai,Ze-Guang Han,Jian-Hua Ni,Gui-Ying Shi,Pei-Ming Jia,Meng-Min Liu,Kai-Li He,Chao Niu,Jun Ma,Peng Zhang,Ting-Dong Zhang,Pascale Paul,Tomoki Naoe,Kunio Kitamura,Wilson H. Miller,Samuel Waxman,Zhen-Yi Wang,Sai-Juan Chen,Zhu Chen +23 more
TL;DR: Combination of induction of apoptosis and partial differention could be the main cellular mechanisms of As2O3 in the treatment of APL, and PML-RAR alpha could play an important role in determining the specific effects of As 2O3 on APL cells.