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Xue-Geng Shi
Publications - 3
Citations - 1656
Xue-Geng Shi is an academic researcher. The author has contributed to research in topics: Acute promyelocytic leukemia & Cellular differentiation. The author has an hindex of 3, co-authored 3 publications receiving 1613 citations.
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Journal ArticleDOI
In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins
Guo-Qiang Chen,Jun Zhu,Xue-Geng Shi,Jian-Hua Ni,Hao-Jie Zhong,Gui-Ying Si,Xiao-Long Jin,Wei Tang,Xiu-Shong Li,Shu-Ming Xong,Zhi-Xiang Shen,Guan-Lin Sun,Jun Ma,Peng Zhang,Ting-Dong Zhang,Claude Gazin,Tomoki Naoe,Sai-Juan Chen,Zhen-Yi Wang,Zhu Chen +19 more
TL;DR: In this paper, As2O3 was shown to trigger NB4 cell apoptosis at micromolar concentration, as proved by morphology, histogramic related nuclear DNA contents, and DNA gel eletrophoresis.
Journal ArticleDOI
Use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia (APL) : I. As2O3 exerts dose-dependent dual effects on APL cells
Guo-Qiang Chen,Xue-Geng Shi,Wei Tang,Shu-Min Xiong,Jun Zhu,Xun Cai,Ze-Guang Han,Jian-Hua Ni,Gui-Ying Shi,Pei-Ming Jia,Meng-Min Liu,Kai-Li He,Chao Niu,Jun Ma,Peng Zhang,Ting-Dong Zhang,Pascale Paul,Tomoki Naoe,Kunio Kitamura,Wilson H. Miller,Samuel Waxman,Zhen-Yi Wang,Sai-Juan Chen,Zhu Chen +23 more
TL;DR: Combination of induction of apoptosis and partial differention could be the main cellular mechanisms of As2O3 in the treatment of APL, and PML-RAR alpha could play an important role in determining the specific effects of As 2O3 on APL cells.
Journal Article
Effect of retinoic acid isomers on proliferation, differentiation and PML relocalization in the APL cell line NB4.
Jun Zhu,Xue-Geng Shi,Haiyan Chu,Jian-Hua Tong,Zhen-yi Wang,Tomoki Naoe,Samuel Waxman,Sai-Juan Chen,Zhu Chen +8 more
TL;DR: The results provide further evidence that 9-cis RA could be a promising molecule in differentiation induction of malignant cells.