Guanjun Cheng

TL;DR: It is suggested that TGF-beta within the tumor microenvironment induces a population of TAN with a protumor phenotype, and depletion of these neutrophils significantly blunts antitumor effects of treatment and reduces CD8(+) T cell activation.

TL;DR: This study characterizes different populations of neutrophils related to cancer, pointing out the major differences between TAN and the other neutrophil populations.

TL;DR: Administration of anti-CCL2/CCL12 antibodies along with the vaccines markedly augmented efficacy with enhanced reduction in tumor volume and cures of approximately half of the tumors, suggesting that combining CCL2 neutralization with vaccines should be considered in future immunotherapy trials.

TL;DR: A complex network of immunosuppression in the surrounding tumor microenvironment explains the resistance of tumor recurrences to conventional cancer vaccines despite small tumor size, an intact antitumor immune response, and unaltered cancer cells.

TL;DR: The data from NSCLC models show that CCL2 blockade can inhibit the tumor growth of primary and metastatic disease, and the mechanisms include an alteration of the tumor macrophage phenotype and the activation of CTLs.