Leona E. Ling

TL;DR: It is suggested that TGF-beta within the tumor microenvironment induces a population of TAN with a protumor phenotype, and depletion of these neutrophils significantly blunts antitumor effects of treatment and reduces CD8(+) T cell activation.

TL;DR: It is shown that Shh functions as a regulator of primitive hematopoietic cells via mechanisms that are dependent on downstream BMP signals, and Noggin, a specific inhibitor of bone morphogenetic protein 4 (BMP-4), was capable of inhibiting Shh-induced proliferation in a similar manner to anti-Hh.

TL;DR: A novel role for Shh is revealed as an indirect angiogenic factor regulating expression of multiple angiogenesis cytokines and potential therapeutic use for ischemic disorders is indicated.

TL;DR: The data show that the N-terminal osteopontin fragment, which contains the RGD domain, supports adhesion of a melanoma cell line that is unable to bind native osteopontoin, which suggests that osteoponin adhesive interactions may be regulated by thrombin cleavage.

TL;DR: This study finds that skeletal muscle ischemia induces strong local upregulation of Shh mRNA and protein, and the Ptc1 receptor is activated in interstitial mesenchymal cells within the ischemic area, indicating that these cells respond to Shh and that the Shh pathway is functional.