G
G. Scott Worthen
Researcher at Children's Hospital of Philadelphia
Publications - 45
Citations - 5301
G. Scott Worthen is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Chemokine & Innate immune system. The author has an hindex of 19, co-authored 39 publications receiving 4273 citations. Previous affiliations of G. Scott Worthen include University of Pennsylvania.
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Journal ArticleDOI
Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: “N1” versus “N2” TAN
Zvi G. Fridlender,Jing Sun,Samuel Kim,Veena Kapoor,Guanjun Cheng,Leona E. Ling,G. Scott Worthen,Steven M. Albelda +7 more
TL;DR: It is suggested that TGF-beta within the tumor microenvironment induces a population of TAN with a protumor phenotype, and depletion of these neutrophils significantly blunts antitumor effects of treatment and reduces CD8(+) T cell activation.
Journal ArticleDOI
The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice
Hitesh Deshmukh,Yuhong Liu,Ogechukwu Menkiti,Junjie Mei,Ning Dai,Claire E. O’Leary,Paula M. Oliver,Jay K. Kolls,Jeffrey N. Weiser,G. Scott Worthen +9 more
TL;DR: A role for the intestinal microbiota in regulation of granulocytosis, neutrophil homeostasis and host resistance to sepsis in neonates is supported.
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An epithelial circadian clock controls pulmonary inflammation and glucocorticoid action
Julie E. Gibbs,Louise Ince,Laura Matthews,Junjie Mei,Thomas J. Bell,Nan Yang,Ben Saer,Nicola Begley,Toryn Poolman,Marie Pariollaud,Stuart N. Farrow,Francesco J. DeMayo,Tracy Hussell,G. Scott Worthen,David W. Ray,Andrew S. I. Loudon +15 more
TL;DR: A regulatory mechanism that links the circadian clock and glucocorticoid hormones to control both time-of-day variation and the magnitude of pulmonary inflammation and responses to bacterial infection is defined.
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Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis.
Benjamin T. Suratt,Joseph M. Petty,Scott K. Young,Kenneth C. Malcolm,Jonathan G. Lieber,Jerry A. Nick,Jose-Angel Gonzalo,Peter M. Henson,G. Scott Worthen +8 more
TL;DR: The results suggest that the CXCR4/SDF-1 axis is critical in circulating neutrophil homeostasis and that it may participate in the rapid release of neutrophils from the marrow during inflammation through a novel interaction with inflammatory CXC chemokines.
Journal ArticleDOI
Enhanced Pseudomonas aeruginosa Biofilm Development Mediated by Human Neutrophils
Travis S. Walker,Kerry L. Tomlin,G. Scott Worthen,Katie R. Poch,Jonathan G. Lieber,Milene T. Saavedra,Michael B. Fessler,Kenneth C. Malcolm,Michael L. Vasil,Jerry A. Nick +9 more
TL;DR: It is shown that the presence of neutrophils enhances initial P. aeruginosa biofilm development over a period of 72 h through the formation of polymers comprised of actin and DNA.