Gudarz Davar

TL;DR: MK-801 may prevent the development of hyperalgesia following experimental nerve injury, possibly through an NMDA receptor-mediated effect.

TL;DR: A new endogenous analgesic circuit is mapped, in which ETB receptor activation induces the release of β-endorphin from keratinocytes and the activation of G-protein-coupled inwardly rectifying potassium channels (GIRKs) linked to opioid receptors on nociceptors.

TL;DR: It is demonstrated that subcutaneous administration of ET-1 to the rat plantar hindpaw produces pain-like behavior and selective excitation of nociceptive fibers through activation of ETAreceptors.

TL;DR: Comparative genomics revealed a conserved ORF corresponding to a novel gene in which three different truncating mutations among five families including patients from rural Quebec and Nova Scotia may play a role in the development and/or maintenance of peripheral sensory neurons or their supporting Schwann cells.

TL;DR: Prior and co-administration of BQ-123, an endothelin-A (ETA) receptor antagonist, also blocked ET-1-induced hindpaw flinching establishing that pain behavior induced by ET- 1 application to rat sciatic nerve is ETA receptor mediated.