G
Gui-Rong Guo
Researcher at Genomics Institute of the Novartis Research Foundation
Publications - 13
Citations - 1597
Gui-Rong Guo is an academic researcher from Genomics Institute of the Novartis Research Foundation. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 4, co-authored 4 publications receiving 1427 citations.
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Journal ArticleDOI
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Jun Liu,Shifeng Pan,Mindy H. Hsieh,Nicholas Ng,Fangxian Sun,Tao Wang,Shailaja Kasibhatla,Alwin Schuller,Allen G. Li,Dai Cheng,Jie Li,Celin Tompkins,Anne Marie Pferdekamper,Auzon Steffy,Jane Cheng,Colleen Kowal,Van Phung,Gui-Rong Guo,Yan Wang,Martin P. Graham,Shannon Flynn,J. Chad Brenner,Chun Li,M. Cristina Villarroel,Peter G. Schultz,Xu Wu,Peter McNamara,William R. Sellers,Lilli Petruzzelli,Anthony Boral,H. Martin Seidel,Margaret E. McLaughlin,Jianwei Che,Thomas E. Carey,Gary J. Vanasse,Jennifer L. Harris +35 more
TL;DR: LGK974 is potent and efficacious in multiple tumor models at well-tolerated doses in vivo, including murine and rat mechanistic breast cancer models driven by MMTV–Wnt1 and a human head and neck squamous cell carcinoma model (HN30).
Journal ArticleDOI
Expansion of Bcr-Abl-positive leukemic stem cells is dependent on Hedgehog pathway activation.
Christine Dierks,Christine Dierks,Ronak Beigi,Gui-Rong Guo,Katja Zirlik,Mario R. Stegert,Paul W. Manley,Christopher Trussell,Annette Schmitt-Graeff,Klemens Landwerlin,Hendrik Veelken,Markus Warmuth,Markus Warmuth +12 more
TL;DR: It is shown that Hedgehog signaling is activated in LSCs through upregulation of Smo, and this indicates that Smo inhibition might be an effective treatment strategy to reduce the LSC pool in CML.
Journal ArticleDOI
Essential role of stromally induced hedgehog signaling in B-cell malignancies
Christine Dierks,Christine Dierks,Jovana Grbic,Katja Zirlik,Ronak Beigi,Nathan P. Englund,Gui-Rong Guo,Hendrik Veelken,Monika Engelhardt,Roland Mertelsmann,Joseph Kelleher,Peter G. Schultz,Peter G. Schultz,Markus Warmuth +13 more
TL;DR: It is demonstrated that hedgehog ligands secreted by bone-marrow, nodal and splenic stromal cells function as survival factors for malignant lymphoma and plasmacytoma cells derived from transgenic Eμ-Myc mice or isolated from humans with these malignancies.
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The ITK-SYK Fusion Oncogene Induces a T-Cell Lymphoproliferative Disease in Mice Mimicking Human Disease
Christine Dierks,Francisco Adrian,Paul Fisch,Hong Ma,Helga Maurer,Dieter Herchenbach,Christine Ulrike Forster,Clara Sprissler,Guoxun Liu,Sabine Rottmann,Gui-Rong Guo,Zirlik Katja,Hendrik Veelken,Markus Warmuth +13 more
TL;DR: It is shown that the expression of ITK-SYK in the bone marrow of BALB/c mice causes a T-cell lymphoproliferative disease in all transplanted mice within 8 weeks after transplantation, supporting its role in T- cell lymphoma development in humans.
Journal ArticleDOI
I226R Protein of African Swine Fever Virus Is a Suppressor of Innate Antiviral Responses
Jinxuan Hong,Xiaojuan Chi,Xu Yuan,Faxin Wen,Kuldeep Rai,Lei Wu,Zhongbao Song,Song Wang,Gui-Rong Guo,Ji-Long Chen +9 more
TL;DR: Results reveal that the ASFV I226R protein impairs antiviral responses, likely through multiple mechanisms including the suppression of NF-κB and IRF3 activation, to counteract innate immune responses during the viral infection.