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Allen G. Li
Researcher at Oregon Health & Science University
Publications - 36
Citations - 4593
Allen G. Li is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Transforming growth factor & Transgene. The author has an hindex of 26, co-authored 36 publications receiving 4141 citations. Previous affiliations of Allen G. Li include Baylor College of Medicine & Novartis.
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Journal ArticleDOI
Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974
Jun Liu,Shifeng Pan,Mindy H. Hsieh,Nicholas Ng,Fangxian Sun,Tao Wang,Shailaja Kasibhatla,Alwin Schuller,Allen G. Li,Dai Cheng,Jie Li,Celin Tompkins,Anne Marie Pferdekamper,Auzon Steffy,Jane Cheng,Colleen Kowal,Van Phung,Gui-Rong Guo,Yan Wang,Martin P. Graham,Shannon Flynn,J. Chad Brenner,Chun Li,M. Cristina Villarroel,Peter G. Schultz,Xu Wu,Peter McNamara,William R. Sellers,Lilli Petruzzelli,Anthony Boral,H. Martin Seidel,Margaret E. McLaughlin,Jianwei Che,Thomas E. Carey,Gary J. Vanasse,Jennifer L. Harris +35 more
TL;DR: LGK974 is potent and efficacious in multiple tumor models at well-tolerated doses in vivo, including murine and rat mechanistic breast cancer models driven by MMTV–Wnt1 and a human head and neck squamous cell carcinoma model (HN30).
Journal ArticleDOI
Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors
Jianming Zhang,Francisco Adrian,Wolfgang Jahnke,Sandra W. Cowan-Jacob,Allen G. Li,Roxana E. Iacob,Taebo Sim,Taebo Sim,John T. Powers,John T. Powers,Christine Dierks,Fangxian Sun,Gui Rong Guo,Qiang Ding,Barun Okram,Yongmun Choi,Amy Wojciechowski,Xianming Deng,Guoxun Liu,Gabriele Fendrich,André Strauss,Navratna Vajpai,Stephan Grzesiek,Tove Tuntland,Yi Liu,Badry Bursulaya,Mohammad Azam,Mohammad Azam,Paul W. Manley,John R. Engen,George Q. Daley,George Q. Daley,Markus Warmuth,Nathanael S. Gray +33 more
TL;DR: The results show that therapeutically relevant inhibition of Bcr–Abl activity can be achieved with inhibitors that bind to the myristate-binding site and that combining allosteric and ATP-competitive inhibitors can overcome resistance to either agent alone.
Journal ArticleDOI
Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-N2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-N4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
Thomas H. Marsilje,Wei Pei,Bei Chen,Wenshuo Lu,Tetsuo Uno,Jin Yunho,Tao Jiang,Sungjoon Kim,Nanxin Li,Markus Warmuth,Yelena Sarkisova,Frank Sun,Auzon Steffy,AnneMarie Culazzo Pferdekamper,Allen G. Li,Sean B. Joseph,Young Kim,Bo Liu,Tove Tuntland,Xiaoming Cui,Nathanael S. Gray,Ruo Steensma,Yongqin Wan,Jiqing Jiang,Chopiuk Greg,Jie Li,W. Perry Gordon,Wendy Richmond,Kevin Johnson,Jonathan Chang,Todd Groessl,You-Qun He,Andrew Phimister,Alex Aycinena,Christian C. Lee,Badry Bursulaya,Donald S. Karanewsky,H. Martin Seidel,Jennifer L. Harris,Pierre-Yves Michellys +39 more
TL;DR: In this initial report, preliminary structure-activity relationships (SARs) are described as well as the rational design strategy employed to overcome the development deficiencies of the first generation ALK inhibitor 4 (TAE684).
Journal ArticleDOI
Induction of sonic hedgehog mediators by transforming growth factor-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo.
Sylviane Dennler,Jocelyne André,Ismini Alexaki,Allen G. Li,Thierry Magnaldo,Peter ten Dijke,Xiaojing Wang,Franck Verrecchia,Alain Mauviel +8 more
TL;DR: It is shown that TGF-beta induces the expression of the Hh signaling molecules Gli1 and Gli2 in various human cell types, including normal fibroblasts and keratinocytes, as well as various cancer cell lines.
Journal ArticleDOI
Signaling Mechanism of TGF-β1 in Prevention of Renal Inflammation: Role of Smad7
Wansheng Wang,Xiao R. Huang,Allen G. Li,Fang Liu,Jinhua Li,Luan D. Truong,Xiao J. Wang,Hui Y. Lan +7 more
TL;DR: LTG-beta may have protective roles in renal inflammation, and Smad7-mediated inhibition of NF-kappaB activation via the induction of IkBalpha may be the central mechanism by which latent TGF-beta prevents renal inflammation.