G
Guido Sanguinetti
Researcher at International School for Advanced Studies
Publications - 232
Citations - 7619
Guido Sanguinetti is an academic researcher from International School for Advanced Studies. The author has contributed to research in topics: Inference & Model checking. The author has an hindex of 47, co-authored 220 publications receiving 6342 citations. Previous affiliations of Guido Sanguinetti include University of Oxford & University of Manchester.
Papers
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Journal ArticleDOI
scNMT-seq enables joint profiling of chromatin accessibility DNA methylation and transcription in single cells.
Stephen J. Clark,Ricard Argelaguet,Chantriolnt-Andreas Kapourani,Thomas M. Stubbs,Heather J. Lee,Heather J. Lee,Heather J. Lee,Celia Alda-Catalinas,Felix Krueger,Guido Sanguinetti,Gavin Kelsey,Gavin Kelsey,John C. Marioni,John C. Marioni,John C. Marioni,Oliver Stegle,Wolf Reik,Wolf Reik,Wolf Reik +18 more
TL;DR: This work reports the first single-cell method for parallel chromatin accessibility, DNA methylation and transcriptome profiling and validate scNMT-seq by applying it to differentiating mouse embryonic stem cells, finding links between all three molecular layers and revealing dynamic coupling between epigenomic layers during differentiation.
Journal ArticleDOI
Approximation and inference methods for stochastic biochemical kinetics—a tutorial review
TL;DR: An introduction to basic modelling concepts as well as an overview of state of the art methods for stochastic chemical kinetics is given, including the chemical Langevin equation, the system size expansion, moment closure approximation, time-scale separation approximations and hybrid methods.
Journal ArticleDOI
Multi-omics profiling of mouse gastrulation at single-cell resolution.
Ricard Argelaguet,Stephen J. Clark,Hisham Mohammed,L. Carine Stapel,Christel Krueger,Chantriolnt-Andreas Kapourani,Ivan Imaz-Rosshandler,Tim Lohoff,Tim Lohoff,Yunlong Xiang,Courtney W. Hanna,Courtney W. Hanna,Sébastien A. Smallwood,Ximena Ibarra-Soria,Florian Buettner,Guido Sanguinetti,Wei Xie,Felix Krueger,Berthold Göttgens,Peter J. Rugg-Gunn,Gavin Kelsey,Gavin Kelsey,Wendy Dean,Jennifer Nichols,Oliver Stegle,Oliver Stegle,John C. Marioni,John C. Marioni,John C. Marioni,Wolf Reik,Wolf Reik,Wolf Reik +31 more
TL;DR: A single-cell multi-omics map of chromatin accessibility, DNA methylation and RNA expression during the onset of gastrulation in mouse embryos shows characteristic epigenetic changes that accompany formation of the primary germ layers.
Book ChapterDOI
Missing data in kernel PCA
TL;DR: The probabilistic interpretation of linear PCA is exploited together with recent results on latent variable models in Gaussian Processes in order to introduce an objective function for KPCA, and this new approach can be extended to reconstruct corrupted test data using fixed kernel feature extractors.
Journal ArticleDOI
Approximation and inference methods for stochastic biochemical kinetics - a tutorial review
TL;DR: In this article, a self-contained introduction to modeling, approximations and inference methods for stochastic chemical kinetics is given, as well as a comparison of several of these methods by means of a numerical case study.