G
Guidong Yao
Researcher at University of Science and Technology of China
Publications - 8
Citations - 700
Guidong Yao is an academic researcher from University of Science and Technology of China. The author has contributed to research in topics: microRNA & Granulosa cell. The author has an hindex of 7, co-authored 8 publications receiving 630 citations. Previous affiliations of Guidong Yao include Zhengzhou University.
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Journal ArticleDOI
MicroRNA-224 Is Involved in Transforming Growth Factor-β-Mediated Mouse Granulosa Cell Proliferation and Granulosa Cell Function by Targeting Smad4
TL;DR: This is the first demonstration that miRNAs can control reproductive functions resulting in promoting TGF-beta1-induced GC proliferation and ovarian estrogen release.
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Downregulation of microRNA-383 is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation by targeting IRF1.
TL;DR: It is shown that downregulation of miR-383 was associated with hyperactive proliferation of germ cells in patients with mixed patterns of MA and functions as a negative regulator of proliferation by targeting IRF1, in part, through inactivation of the pRb pathway.
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Transactivation of microRNA-383 by steroidogenic factor-1 promotes estradiol release from mouse ovarian granulosa cells by targeting RBMS1
TL;DR: The results suggest that miR-383 functions to promote steroidogenesis by targeting RBMS1, at least in part, through inactivation of c-Myc, and SF-1 acts as a positive regulator of miR's processing and function in GC.
Journal ArticleDOI
Transcriptional cooperation between p53 and NF-κB p65 regulates microRNA-224 transcription in mouse ovarian granulosa cells
Meng Liang,Guidong Yao,Guidong Yao,Mianmian Yin,Mingrong Lü,Hui Tian,Lin Liu,Jie Lian,Xingxu Huang,Fei Sun +9 more
TL;DR: Results showed that both the tumor suppressor gene p53 and NF-κB p65 subunit suppressed the TGF-β1-induced increase in pri-miR-224 expression in GCs, and provided new data about the interplay between transcription factors involved in GC proliferation and function by cooperatively regulating miRNA expression.
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MicroRNA-224 is involved in the regulation of mouse cumulus expansion by targeting Ptx3
TL;DR: Results indicate that miR-224 may affect ovulation and subsequent embryo development by targeting Ptx3, suggesting potential roles for miRNAs in offering new treatments for ovulation disorder-associated infertility, or, conversely, designing new contraceptives.