Guillaume Chazot

TL;DR: It is shown that, in the absence of netrin-1, recruitment of PP2A to UNC5H2/B allows the activation of DAPk via aPP2A-mediated dephosphorylation and that this mechanism is involved in angiogenesis regulation.

TL;DR: It is demonstrated that DCC functions as a tumour suppressor via its ability to trigger tumour cell apoptosis, which is associated with an increase in the number and aggressiveness of intestinal tumours in a predisposing APC mutant context.

TL;DR: It is described for the first time a major physiological function of SelN in skeletal muscles, as a key regulator of SC function, which likely plays a central role in the pathophysiological mechanism leading to SEPN1-RM.

TL;DR: Using a transgenic mouse model, it is reported here that inhibition of DCC‐induced apoptosis is associated with lymphomagenesis and interference with the netrin‐1/DCC interaction could represent a promising therapeutic strategy in netrin•1‐positive DLBCL and MCL.

TL;DR: Phosphorus magnetic resonance spectroscopy examination of patients with ESKD during hemodialysis treatment confirmed that depurated Pi originates from the intracellular compartment, raising the possibility that excessive dialytic depuration of phosphate might adversely affect the intrACEllular availability of high-energy phosphates and ultimately, cellular metabolism.