L
Laetitia Mazelin
Researcher at University of Lyon
Publications - 15
Citations - 1752
Laetitia Mazelin is an academic researcher from University of Lyon. The author has contributed to research in topics: Dependence receptor & Deleted in Colorectal Cancer. The author has an hindex of 13, co-authored 13 publications receiving 1612 citations. Previous affiliations of Laetitia Mazelin include École normale supérieure de Lyon & Centre national de la recherche scientifique.
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Journal ArticleDOI
Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy
Valérie Risson,Laetitia Mazelin,Mila Roceri,Hervé Sanchez,Vincent Moncollin,Claudine Corneloup,Hélène Richard-Bulteau,Alban Vignaud,Dominique Baas,Aurelia Defour,Damien Freyssenet,Jean-François Tanti,Jean-François Tanti,Yannick Le-Marchand-Brustel,Yannick Le-Marchand-Brustel,Bernard Ferrier,Agnès Conjard-Duplany,Klaas Romanino,S. Bauche,Daniel Hantaï,Matthias Mueller,Sara C. Kozma,George Thomas,Markus A. Rüegg,Arnaud Ferry,Mario Pende,Xavier Bigard,Nathalie Koulmann,Laurent Schaeffer,Yann-Gaël Gangloff +29 more
TL;DR: mTor, acting mainly via mTORC1, controls dystrophin transcription in a raptor- and rictor-independent mechanism.
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Inhibition of Neuroepithelial Patched-Induced Apoptosis by Sonic Hedgehog
Chantal Thibert,Marie-Aimée Teillet,Françoise Lapointe,Laetitia Mazelin,Nicole M. Le Douarin,Patrick Mehlen +5 more
TL;DR: It is shown that Patched induces apoptotic cell death unless its ligand Shh is present to block the signal, and the blockade of Ptc-induced cell death partly rescues the chick spinal cord defect provoked by Shh deprivation.
Journal ArticleDOI
Netrin-1 controls colorectal tumorigenesis by regulating apoptosis.
Laetitia Mazelin,Agnès Bernet,Christelle Bonod-Bidaud,Laurent Pays,Ségolène Arnaud,Christian Gespach,Dale E. Bredesen,Jean-Yves Scoazec,Patrick Mehlen +8 more
TL;DR: It is shown that inhibition of cell death by enforced expression of netrin-1 in mouse gastrointestinal tract leads to the spontaneous formation of hyperplastic and neoplastic lesions, and it is demonstrated that netin-1 can promote intestinal tumour development, probably by regulating cell survival.
Journal ArticleDOI
The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.
Karine Thiébault,Laetitia Mazelin,Laurent Pays,Fabien Llambi,Marie-Odile Joly,Jean-Yves Scoazec,Jean-Christophe Saurin,Giovanni Romeo,Patrick Mehlen +8 more
TL;DR: It is shown here that the expression of the human UNC5A, UNC5B, or UNC5C is down-regulated in multiple cancers including colorectal, breast, ovary, uterus, stomach, lung, or kidney cancers.
Journal ArticleDOI
Inactivation of the UNC5C Netrin-1 Receptor Is Associated With Tumor Progression in Colorectal Malignancies
Agnès Bernet,Laetitia Mazelin,Marie–May Coissieux,Nicolas Gadot,Susan L. Ackerman,Jean-Yves Scoazec,Jean-Yves Scoazec,Patrick Mehlen,Patrick Mehlen +8 more
TL;DR: It is shown that UNC5C expression is down-regulated in a large fraction of human colorectal cancers, mainly through promoter methylation, and in mice, inactivation of UNC5C is associated with increased intestinal tumor progression and a decrease in tumor cell apoptosis.