G
Guillaume Lautrette
Researcher at Massachusetts Institute of Technology
Publications - 13
Citations - 578
Guillaume Lautrette is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Foldamer & Peptide. The author has an hindex of 10, co-authored 13 publications receiving 481 citations. Previous affiliations of Guillaume Lautrette include University of Bordeaux & Centre national de la recherche scientifique.
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Journal ArticleDOI
Iterative design of a helically folded aromatic oligoamide sequence for the selective encapsulation of fructose
Nagula Chandramouli,Yann Ferrand,Yann Ferrand,Guillaume Lautrette,Guillaume Lautrette,Brice Kauffmann,Cameron D. Mackereth,Michel Laguerre,Michel Laguerre,Didier Dubreuil,Ivan Huc,Ivan Huc +11 more
TL;DR: A powerful approach to produce receptors with very high selectivity for specific monosaccharides and, as a demonstration, a foldamer that selectively encapsulates fructose is developed.
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Palladium-Mediated Arylation of Lysine in Unprotected Peptides.
TL;DR: In this article, a mild method for the arylation of lysine in an unprotected peptide is presented, in the presence of a preformed biarylphosphine-supported palladium(II)-aryl complex and a weak base.
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Nitrogen Arylation for Macrocyclization of Unprotected Peptides
TL;DR: It was found that nitrogen-linked aryl products were more stable to base and oxidation when compared to thiol arylated species, thereby highlighting the utility of this methodology.
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In-solution enrichment identifies peptide inhibitors of protein-protein interactions.
TL;DR: In this article, a platform for improving the affinity of peptide-based PPI inhibitors using non-canonical amino acids is presented, which utilizes size exclusion-based enrichment from pools of synthetic peptides and liquid chromatography-tandem mass spectrometry-based peptide sequencing to identify high affinity binders to protein targets.
Journal ArticleDOI
Iterative Evolution of an Abiotic Foldamer Sequence for the Recognition of Guest Molecules with Atomic Precision
Guillaume Lautrette,Guillaume Lautrette,Barbara Wicher,Barbara Wicher,Brice Kauffmann,Brice Kauffmann,Brice Kauffmann,Yann Ferrand,Yann Ferrand,Ivan Huc,Ivan Huc +10 more
TL;DR: The results demonstrate the viability of a rational receptor design approach that exploits the modularity of foldamer sequences and, in the case of aromatic amide foldamers, their amenability to structural elucidation, their relative ease of synthesis, and the predictability of their structure.