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Bradley L. Pentelute
Researcher at Massachusetts Institute of Technology
Publications - 186
Citations - 7397
Bradley L. Pentelute is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Peptide & Chemistry. The author has an hindex of 40, co-authored 166 publications receiving 5618 citations. Previous affiliations of Bradley L. Pentelute include University of Chicago & Broad Institute.
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Journal ArticleDOI
Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
Basil P. Hubbard,Ana P. Gomes,Ana P. Gomes,Han Dai,Jun Li,April Case,Thomas Considine,Thomas V. Riera,Jessica E. Lee,Sook Yen E,Dudley W. Lamming,Bradley L. Pentelute,Eli Schuman,Linda A. Stevens,Alvin J. Y. Ling,Sean M. Armour,Shaday Michan,Huizhen Zhao,Yong Jiang,Sharon Sweitzer,Charles A. Blum,Jeremy S. Disch,Pui Yee Ng,Konrad T. Howitz,Anabela P. Rolo,Anabela P. Rolo,Yoshitomo Hamuro,Joel Moss,Robert B. Perni,James L. Ellis,George P. Vlasuk,David A. Sinclair,David A. Sinclair +32 more
TL;DR: SIRT1 can be directly activated through an allosteric mechanism common to chemically diverse STACs, and specific hydrophobic motifs found in SIRT1 substrates such as PGC-1α and FOXO3a facilitate Sirtuin-activating compounds (STACs) activation by STacs.
Evidence for a Common Mechanism of SIRT1 Regulation by Allosteric Activators
Basil P. Hubbard,Ana P. Gomes,Han Dai,Jun Li,April Case,Thomas Considine,Thomas V. Riera,Jessica E. Lee,E. Sook Yen,Dudley W. Lamming,Eli Schuman,Linda Stevens,Alvin J. Y. Ling,Sean M. Armour,Shaday Michan,Huizhen Zhao,Yong Jiang,Sharon Sweitzer,Charles A. Blum,Jeremy S. Disch,Pui Yee Ng,Konrad T. Howitz,Anabela P. Rolo,Yoshitomo Hamuro,Joel Moss,Robert B. Perni,James L. Ellis,George P. Vlasuk,David A. Sinclair,Bradley L. Pentelute +29 more
TL;DR: Yuan et al. as mentioned in this paper found that specific hydrophobic motifs found in SIRT1 substrates such as PGC-1α and FOXO3a facilitate SIRT 1 activation by STACs.
Journal ArticleDOI
A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling
Alexander M. Spokoyny,Yekui Zou,Jingjing J. Ling,Hongtao Yu,Yu-Shan Lin,Bradley L. Pentelute +5 more
TL;DR: This stapling modification performed on a peptide sequence designed to bind the C-terminal domain of an HIV-1 capsid assembly polyprotein (C-CA) showed enhancement in binding, cell permeability, and proteolytic stability properties, as compared to the unstapled analog.
Journal ArticleDOI
Organometallic palladium reagents for cysteine bioconjugation
Ekaterina V. Vinogradova,Chi Zhang,Alexander M. Spokoyny,Bradley L. Pentelute,Stephen L. Buchwald +4 more
TL;DR: It is reported that palladium(ii) complexes can be used for efficient and highly selective cysteine conjugation (bioconjugation) reactions that are rapid and robust under a range of bio-compatible reaction conditions.
Organometallic palladium reagents for cysteine bioconjugation
Ekaterina V. Vinogradova,Chi Zhang,Alexander M. Spokoyny,Bradley L. Pentelute,Stephen L. Buchwald +4 more
TL;DR: In this article, the palladium(II) complexes were used for efficient and highly selective cysteine conjugation (bioconjugation) reactions that are rapid and robust under a range of bio-compatible reaction conditions.