G
Guolin Zhang
Researcher at Xiamen University
Publications - 20
Citations - 604
Guolin Zhang is an academic researcher from Xiamen University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 10, co-authored 12 publications receiving 479 citations.
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Journal ArticleDOI
Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors
Yun Bai,Jiannong Li,Bin Fang,Arthur Edwards,Guolin Zhang,Marilyn M. Bui,Steven A. Eschrich,Soner Altiok,John M. Koomen,Eric B. Haura +9 more
TL;DR: The findings suggest that integrating global phosphoproteomics with functional analyses with kinase inhibitors can identify drivers of sarcoma growth and survival.
Journal ArticleDOI
Targeting epidermal growth factor receptor: central signaling kinase in lung cancer.
TL;DR: The significance of EGFR mutations and the mechanisms of resistance to EGFR-TKIs in NSCLC, both of which are critical for patient selection to extend survival as well as to overcome resistance, are summarized.
Journal ArticleDOI
Tyrosine Phosphoproteomics Identifies Both Codrivers and Cotargeting Strategies for T790M-Related EGFR-TKI Resistance in Non–Small Cell Lung Cancer
Takeshi Yoshida,Guolin Zhang,Matthew A. Smith,Alexis S. Lopez,Yun Bai,Jiannong Li,Bin Fang,John M. Koomen,Bhupendra Rawal,Kate Fisher,Y. Ann Chen,Michiko Kitano,Yume Morita,Haruka Yamaguchi,Kiyoko Shibata,Takafumi Okabe,Isamu Okamoto,Kazuhiko Nakagawa,Eric B. Haura +18 more
TL;DR: The results identified both codrivers of resistance along with T790M and support further studies of irreversible or T790m-selective EGFR inhibitors combined with dasatinib in patients with NSCLC with acquired T790 M.
Journal ArticleDOI
Proteogenomic landscape of squamous cell lung cancer.
Paul A. Stewart,Eric A. Welsh,Robbert J.C. Slebos,Bin Fang,Victoria Izumi,Matthew C. Chambers,Guolin Zhang,Ling Cen,Fredrik Pettersson,Yonghong Zhang,Zhihua Chen,Chia-Ho Cheng,Ram Thapa,Zachary J. Thompson,Katherine Fellows,Jewel M Francis,James Saller,Tania Mesa,Chaomei Zhang,Sean Yoder,Gina M. DeNicola,Amer A. Beg,Theresa A. Boyle,Jamie K. Teer,Yian Ann Chen,John M. Koomen,Steven A. Eschrich,Eric B. Haura +27 more
TL;DR: An integrated proteogenomic analysis of the disease is performed, revealing three proteomics-based subtypes and suggesting potential therapeutic opportunities based on redox metabolism and immune cell infiltrates.
Journal ArticleDOI
Mass spectrometry mapping of epidermal growth factor receptor phosphorylation related to oncogenic mutations and tyrosine kinase inhibitor sensitivity.
Guolin Zhang,Bin Fang,Richard Z. Liu,Hui-Yi Lin,Fumi Kinose,Yun Bai,Umut Oguz,Elizabeth R. Remily-Wood,Jiannong Li,Soner Altiok,Steven A. Eschrich,John M. Koomen,Eric B. Haura +12 more
TL;DR: The epidermal growth factor receptor (EGFR) plays an important role in cancer by activating downstream signals important in growth and survival and can identify relationships between somatic mutations or drug sensitivity and protein phosphorylation.