F
Fredrik Pettersson
Researcher at Wellcome Trust Centre for Human Genetics
Publications - 30
Citations - 2391
Fredrik Pettersson is an academic researcher from Wellcome Trust Centre for Human Genetics. The author has contributed to research in topics: Population & Gene. The author has an hindex of 15, co-authored 30 publications receiving 2083 citations. Previous affiliations of Fredrik Pettersson include Wellcome Trust & Umeå University.
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Journal ArticleDOI
Data quality control in genetic case-control association studies
Carl A. Anderson,Fredrik Pettersson,Geraldine M. Clarke,Lon R. Cardon,Andrew P. Morris,Krina T. Zondervan +5 more
TL;DR: This protocol details the steps for data quality assessment and control that are typically carried out during case-control association studies, including the identification and removal of DNA samples and markers that introduce bias.
Journal ArticleDOI
Basic statistical analysis in genetic case-control studies
Geraldine M. Clarke,Carl A. Anderson,Fredrik Pettersson,Lon R. Cardon,Andrew P. Morris,Krina T. Zondervan +5 more
TL;DR: This protocol describes how to perform basic statistical analysis in a population-based genetic association case-control study and uses popular tools for handling single-nucleotide polymorphism data in order to carry out tests of association and visualize and interpret results.
Journal ArticleDOI
Leprosy and the adaptation of human toll-like receptor 1.
Sunny H. Wong,Sailesh Gochhait,Dheeraj Malhotra,Fredrik Pettersson,Yik Y. Teo,Chiea Chuen Khor,Chiea Chuen Khor,Anna Rautanen,Stephen J Chapman,Tara C. Mills,Amit Kumar Srivastava,Aleksey A Rudko,Maxim B. Freidin,Maxim B. Freidin,V. P. Puzyrev,Shafat Ali,Shweta Aggarwal,Rupali Chopra,Belum Siva Nagi Reddy,Vijay K Garg,S. Roy,Sarah Meisner,Sunil K. Hazra,Bibhuti Saha,Sian Floyd,Brendan J. Keating,Cecilia Kim,Benjamin P. Fairfax,Julian C. Knight,Philip C. Hill,Richard A. Adegbola,Hakon Hakonarson,Paul E. M. Fine,Ramasamy Pitchappan,Rameshwar N. K. Bamezai,Adrian V. S. Hill,Fredrik O. Vannberg +36 more
TL;DR: An association analysis of more than 1,500 individuals from different case-control and family studies observations provide insight into the long standing host-pathogen relationship between human and mycobacteria and highlight the key role of the TLR pathway in infectious diseases.
Journal ArticleDOI
Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.
Carl A. Anderson,Fredrik Pettersson,Jeffrey C. Barrett,Joanna J. Zhuang,Jiannis Ragoussis,Lon R. Cardon,Andrew P. Morris +6 more
TL;DR: Gains in power and coverage are quantified by using 1,376 population controls that are from the 1958 British Birth Cohort and were genotyped by the Wellcome Trust Case-Control Consortium with the Illumina HumanHap 550 and Affymetrix SNP Array 5.0 platforms.
Journal ArticleDOI
Variability of gene expression profiles in human blood and lymphoblastoid cell lines
Josine L. Min,Amy Barrett,Tim Watts,Fredrik Pettersson,Helen Lockstone,Cecilia M. Lindgren,Jennifer M. Taylor,Maxine Allen,Krina T. Zondervan,Mark I. McCarthy +9 more
TL;DR: Gene expression profiles in blood-based samples are strongly dependent on the predominant constituent cell type(s) and RNA isolation method, and their relevance to disease processes, before application in large clinical studies.