Guttorm Haraldsen

TL;DR: The results suggest that CCR4 and TARC are important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to their target tissues.

TL;DR: Tissue-specific expression patterns in different tissue microvascular ECs suggest they are distinct differentiated cell types that play roles in the local physiology of their respective organs and tissues.

TL;DR: Results imply a restricted role for lymphocyte CCR9 and its ligand TECK in the small intestine, and provide the first evidence for distinctive mechanisms of lymphocyte recruitment that may permit functional specialization of immune responses in different segments of the gastrointestinal tract.

TL;DR: In situ hybridization and immunohistochemistry revealed that NF-HEV mRNA and protein are expressed at high levels and rather selectively by HEVECs in human tonsils, Peyers's patches, and lymph nodes, and threading and molecular modeling studies suggested that the amino-terminal part of NF- HEV corresponds to a novel homeodomain-like Helix-Turn-Helix (HTH) DNA-binding domain.

TL;DR: A mechanism for immunosurveillance of MHC-II-negative cancer cells by tumor-specific CD4+ T cells by collaboration with macrophages through collaboration with T cell-derived IFNgamma is indicated.