L
Lijun Wu
Researcher at Millennium Pharmaceuticals
Publications - 51
Citations - 14542
Lijun Wu is an academic researcher from Millennium Pharmaceuticals. The author has contributed to research in topics: Chemokine receptor & CC chemokine receptors. The author has an hindex of 36, co-authored 48 publications receiving 14193 citations. Previous affiliations of Lijun Wu include Stanford University & Harvard University.
Papers
More filters
Journal ArticleDOI
The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
Hyeryun Choe,Michael Farzan,Ying Sun,Nancy Sullivan,Barrett J. Rollins,Paul D. Ponath,Lijun Wu,Charles R. Mackay,Gregory J. LaRosa,Walter Newman,Norma P. Gerard,Craig Gerard,Joseph Sodroski +12 more
TL;DR: The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV- 1 isolates.
Journal ArticleDOI
CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
Lijun Wu,Norma P. Gerard,Richard T. Wyatt,Hyeryun Choe,Cristina Parolin,Nancy Ruffing,Alessândra Borsetti,Angelo A. Cardoso,Elizabeth Desjardin,Walter Newman,Craig Gerard,Joseph Sodroski +11 more
TL;DR: It is suggested that HIV-1 attachment to CD4 creates a high-affinity binding site for CCR-5, leading to membrane fusion and virus entry.
Journal ArticleDOI
The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes
TL;DR: The largely reciprocal expression of CXCR4 and CCR5 among peripheral blood T cells implies distinct susceptibility of T cell subsets to viral entry by T cell line- Tropic versus macrophage-tropic strains during the course of HIV infection.
Journal ArticleDOI
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
James Campbell,James Campbell,Guttorm Haraldsen,Guttorm Haraldsen,Guttorm Haraldsen,Junliang Pan,James B. Rottman,S. Qin,Paul D. Ponath,David P. Andrew,Roger A. Warnke,Nancy Ruffing,Nasim Kassam,Lijun Wu,Eugene C. Butcher,Eugene C. Butcher +15 more
TL;DR: The results suggest that CCR4 and TARC are important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to their target tissues.
Journal ArticleDOI
CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro
Lijun Wu,William A. Paxton,Nasim Kassam,Nancy Ruffing,James B. Rottman,Nancy Sullivan,Hyeryun Choe,Joseph Sodroski,Walter Newman,Richard A. Koup,Charles R. Mackay +10 more
TL;DR: Anti-CCR5 mAbs were poor inhibitors of chemokine binding, indicating that HIV-1 and ligands bind to separate, but overlapping regions of CCR5, and demonstrate the feasibility of blocking macrophage-tropic HIV- 1 entry into cells with an anti-CCr5 reagent.