Guy Zinman

TL;DR: Male, but not female, transgenic mice overexpressing Sirt6 have a significantly longer lifespan than wild-type mice, and has important therapeutic implications for age-related diseases.

TL;DR: This work collected comprehensive high-throughput interaction datasets for four model organisms and carried out systematic analyses to explain the apparent lower conservation of interaction data when compared to the conservation of sequence data, showing that conservation is maintained between species, but mainly at the module level.

TL;DR: It is found that only Saccharomyces becomes more azole resistant in ergosterol-supplemented media; that this depends on sterol importers Aus1 and Pdr11; and that transgenic expression of sterolImporters in Kluyveromyces alleviates its drug sensitivity.

TL;DR: This work developed ExpressionBlast, a computational method that uses automated text analysis to identify and merge replicates and determine the type of each array in the series, which allowed us to create the largest collection of computationally annotated expression data currently available.

TL;DR: A core set of genes, activated in both species and across all pathogens that were predominantly part of the interferon response pathway were identified and identified similarities across species in the way innate immune cells respond to lethal versus non-lethal pathogens.