Dwight Kuo

TL;DR: Using an approach called differential epistasis mapping, widespread changes in genetic interaction are discovered among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage, uncovering many gene functions that go undetected in static conditions.

TL;DR: The dynamic ethylene transcriptional response is characterized by identifying targets of the master regulator of the ethylene signaling pathway, EIN3, using chromatin immunoprecipitation sequencing and transcript sequencing during a timecourse of ethylene treatment, providing direct evidence linking each of the major plant growth and development networks in novel ways.

TL;DR: Comparison with an integrated genetic interactome from the budding yeast Saccharomyces cerevisiae revealed a hierarchical model for the evolution of genetic interactions, with conservation highest within protein complexes, lower within biological processes, and lowest between distinct biological processes.

TL;DR: The networks obtained show a wide variety of topologies and numbers of genes indicating that it is relatively easy to evolve these classes of dynamics in this model, indicating that the topologies inherent in natural networks may be in part due to their method of creation rather than being exclusively shaped by subsequent evolution under selection.

TL;DR: It is concluded that MBF‐regulated genes are distinguished from SBF‐ regulated genes by their sensitivity to activation by the S‐phase checkpoint, thereby, providing an effective mechanism for enhancing DNA replication and repair and promoting genome stability.