G
Guy Zinman
Researcher at Carnegie Mellon University
Publications - 7
Citations - 1045
Guy Zinman is an academic researcher from Carnegie Mellon University. The author has contributed to research in topics: Gene & Innate immune system. The author has an hindex of 7, co-authored 7 publications receiving 918 citations.
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Journal ArticleDOI
The sirtuin SIRT6 regulates lifespan in male mice
Yariv Kanfi,Shoshana Naiman,Gail Amir,Victoria Peshti,Guy Zinman,Liat Nahum,Ziv Bar-Joseph,Haim Y. Cohen +7 more
TL;DR: Male, but not female, transgenic mice overexpressing Sirt6 have a significantly longer lifespan than wild-type mice, and has important therapeutic implications for age-related diseases.
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Biological interaction networks are conserved at the module level
TL;DR: This work collected comprehensive high-throughput interaction datasets for four model organisms and carried out systematic analyses to explain the apparent lower conservation of interaction data when compared to the conservation of sequence data, showing that conservation is maintained between species, but mainly at the module level.
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Evolutionary divergence in the fungal response to fluconazole revealed by soft clustering.
TL;DR: It is found that only Saccharomyces becomes more azole resistant in ergosterol-supplemented media; that this depends on sterol importers Aus1 and Pdr11; and that transgenic expression of sterolImporters in Kluyveromyces alleviates its drug sensitivity.
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ExpressionBlast: mining large, unstructured expression databases
TL;DR: This work developed ExpressionBlast, a computational method that uses automated text analysis to identify and merge replicates and determine the type of each array in the series, which allowed us to create the largest collection of computationally annotated expression data currently available.
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Large scale comparison of innate responses to viral and bacterial pathogens in mouse and macaque.
Guy Zinman,Rachel Brower-Sinning,Chineye D. Emeche,Jason Ernst,Grace T. Huang,Shaun Mahony,Amy J. Myers,Dawn M. O'Dee,JoAnne L. Flynn,Gerard J. Nau,Ted M. Ross,Russell D. Salter,Panayiotis V. Benos,Ziv Bar Joseph,Penelope A. Morel +14 more
TL;DR: A core set of genes, activated in both species and across all pathogens that were predominantly part of the interferon response pathway were identified and identified similarities across species in the way innate immune cells respond to lethal versus non-lethal pathogens.