G
Guy Zoltsman
Researcher at Weizmann Institute of Science
Publications - 2
Citations - 79
Guy Zoltsman is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Molecular recognition & Structural biology. The author has an hindex of 1, co-authored 2 publications receiving 47 citations.
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Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions
Ashok Sekhar,Algirdas Velyvis,Guy Zoltsman,Rina Rosenzweig,Guillaume Bouvignies,Lewis E. Kay +5 more
TL;DR: This work directly quantify the flux along CS and IF pathways using solution NMR spectroscopy that exploits a methyl TROSY effect and selective isotope-labeling methodologies and establishes that both bacterial and human Hsp70 chaperones interact with clients by selecting the unfolded state from a pre-existing array of interconverting structures.
Journal ArticleDOI
Structural basis for UFM1 transfer from UBA5 to UFC1.
Manoj Kumar,Prasanth Padala,Prasanth Padala,Jamal Fahoum,Fouad Hassouna,Tomer Tsaban,Guy Zoltsman,Sayanika Banerjee,Einav Cohen-Kfir,Moshe Dessau,Rina Rosenzweig,Michail N. Isupov,Ora Schueler-Furman,Reuven Wiener +13 more
TL;DR: In this paper, the crystal structure of UFC1 bound to the C-terminus of UBA5 was presented, revealing how UBA-5 interacts with UFC1 via a short linear sequence, not observed in other E1-E2 complexes.