G
Gwendolen C. Reilly
Researcher at University of Sheffield
Publications - 110
Citations - 6775
Gwendolen C. Reilly is an academic researcher from University of Sheffield. The author has contributed to research in topics: Mesenchymal stem cell & Tissue engineering. The author has an hindex of 40, co-authored 106 publications receiving 5871 citations. Previous affiliations of Gwendolen C. Reilly include Penn State Milton S. Hershey Medical Center & Pennsylvania State University.
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Journal ArticleDOI
Intrinsic extracellular matrix properties regulate stem cell differentiation
TL;DR: The emergence of stem cell mechanobiology and its future challenges with new biomimetic, three-dimensional scaffolds that are being used therapeutically to treat disease are presented.
Journal ArticleDOI
Osteopontin Gene Regulation by Oscillatory Fluid Flow via Intracellular Calcium Mobilization and Activation of Mitogen-activated Protein Kinase in MC3T3–E1 Osteoblasts
Jun You,Gwendolen C. Reilly,Xuechu Zhen,Clare E. Yellowley,Qian Chen,Henry J. Donahue,Christopher R. Jacobs,Christopher R. Jacobs +7 more
TL;DR: Oscillatory fluid flow was demonstrated to be a potentially important physical signal for loading-induced changes in bone cell metabolism and experiments using a variety of pharmacological agents suggest that oscillatory flow induces Ca2+ i mobilization via the L-type voltage-operated calcium channel and the inositol 1,4,5-trisphosphate pathway.
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Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone
Brendon Noble,Brendon Noble,Nicky M. Peet,Hazel Y. Stevens,Hazel Y. Stevens,Alex C. Brabbs,John R. Mosley,Gwendolen C. Reilly,Jonathan Reeve,Timothy M. Skerry,Lance E. Lanyon +10 more
TL;DR: The data suggest that osteocytes might use their U-shaped survival response to strain as a mechanism to influence bone remodeling, and hypothesize that this relationship reflects a causal mechanism by which osteocyte apoptosis regulates bone's structural architecture.
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Effects of ionizing radiation on the mechanical properties of human bone
TL;DR: It is suggested that because the level of radiation required to produce an acceptable level of viral inactivation (90 kGy) produces an unacceptable reduction in the mechanical integrity of the bone, low levels of radiation, sufficient to produce bacterial safety, should be used in conjunction with biological tests to ensure viral safety.
Journal ArticleDOI
Shear stress induces osteogenic differentiation of human mesenchymal stem cells.
TL;DR: It is demonstrated that shear stress stimulates hMSCs towards an osteoblastic phenotype in the absence of chemical induction, suggesting that certain mechanical stresses may serve as an alternative to chemical stimulation of stem cell differentiation.