J
Jonathan Reeve
Researcher at University of Oxford
Publications - 261
Citations - 18665
Jonathan Reeve is an academic researcher from University of Oxford. The author has contributed to research in topics: Osteoporosis & Bone density. The author has an hindex of 65, co-authored 261 publications receiving 17506 citations. Previous affiliations of Jonathan Reeve include Northwick Park Hospital & University of Cambridge.
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Journal ArticleDOI
Predictive Value of BMD for Hip and Other Fractures
Olof Johnell,John A. Kanis,Anders Odén,Helena Johansson,Chris De Laet,Pierre D. Delmas,John A. Eisman,Seiko Fujiwara,Heikki Kröger,Dan Mellström,Pierre J. Meunier,L. Joseph Melton,T W O'Neill,Huibert A. P. Pols,Jonathan Reeve,Alan J. Silman,Alan Tenenhouse +16 more
TL;DR: The relationship between BMD and fracture risk was estimated in a meta‐analysis of data from 12 cohort studies of ∼39,000 men and women and low hip BMD was an important predictor of fracture risk.
Journal ArticleDOI
The use of clinical risk factors enhances the performance of BMD in the prediction of hip and osteoporotic fractures in men and women.
John A. Kanis,Anders Odén,Olof Johnell,Helena Johansson,C De Laet,Jacques P. Brown,Peter Burckhardt,Cyrus Cooper,Claus Christiansen,Steven R. Cummings,John A. Eisman,S. Fujiwara,C.-C. Glüer,David Goltzman,Didier Hans,M-A Krieg,A.Z. La Croix,Eugene V. McCloskey,Dan Mellström,Lee J. Melton,Huib A.P. Pols,Jonathan Reeve,Kerrie M. Sanders,A. M. Schott,Alan J. Silman,David J. Torgerson,T. P. van Staa,Nelson B. Watts,Noriko Yoshimura +28 more
TL;DR: BMD and clinical risk factors predict hip and other osteoporotic fractures with higher specificity and sensitivity than either alone and provide the basis for the integrated use of validated Clinical risk factors in men and women to aid in fracture risk prediction.
Journal ArticleDOI
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture
Karol Estrada,Unnur Styrkarsdottir,Evangelos Evangelou,Yi-Hsiang Hsu,Emma L. Duncan,Evangelia E. Ntzani,Ling Oei,Omar M. E. Albagha,Najaf Amin,John P. Kemp,Daniel L. Koller,Guo Shuai Li,Ching-Ti Liu,Ryan L. Minster,Alireza Moayyeri,Liesbeth Vandenput,Dana Willner,Su-Mei Xiao,Laura M. Yerges-Armstrong,Hou-Feng Zheng,Nerea Alonso,Joel Eriksson,Candace M. Kammerer,Stephen Kaptoge,Paul Leo,Gudmar Thorleifsson,Scott Wilson,Scott Wilson,James F. Wilson,Ville Aalto,Ville Aalto,Markku Alen,Aaron K. Aragaki,Thor Aspelund,Zoe H. Dailiana,David Duggan,Melissa Nolan Garcia,Natalia Garcia-Giralt,Sylvie Giroux,Göran Hallmans,Lynne J. Hocking,L. B. Husted,Karen A. Jameson,Khusainova Ri,Ghi Su Kim,Charles Kooperberg,Theodora Koromila,Marcin Kruk,Marika Laaksonen,Andrea Z. LaCroix,Seung-Hun Lee,P. C. Leung,Joshua R. Lewis,Laura Masi,Simona Mencej-Bedrač,Tuan V. Nguyen,Tuan V. Nguyen,Xavier Nogués,Millan S. Patel,Janez Prezelj,Lynda M. Rose,Serena Scollen,Kristin Siggeirsdottir,Albert V. Smith,Olle Svensson,Stella Trompet,Olivia Trummer,Natasja M. van Schoor,Jean Woo,Kun Zhu,Susana Balcells,Maria Luisa Brandi,Brendan M. Buckley,Sulin Cheng,Claus Christiansen,Cyrus Cooper,George Dedoussis,Ian Ford,Morten Frost,Morten Frost,David Goltzman,Jesús González-Macías,Mika Kähönen,Magnus Karlsson,Elza Khusnutdinova,Jung-Min Koh,Panagoula Kollia,Bente L. Langdahl,William D. Leslie,Paul Lips,Östen Ljunggren,Roman S. Lorenc,Janja Marc,Dan Mellström,Barbara Obermayer-Pietsch,José M. Olmos,Ulrika Pettersson-Kymmer,David M. Reid,José A. Riancho,Paul M. Ridker,François Rousseau,P. Eline Slagboom,Nelson Ls Tang,Roser Urreizti,Wim Van Hul,Jorma Viikari,María T. Zarrabeitia,Yurii S. Aulchenko,Martha C. Castaño-Betancourt,Elin Grundberg,Elin Grundberg,Lizbeth Herrera,Thorvaldur Ingvarsson,Hrefna Johannsdottir,Tony Kwan,Rui Jian Li,Robert Luben,Carolina Medina-Gomez,Stefan T Palsson,Sjur Reppe,Jerome I. Rotter,Gunnar Sigurdsson,Joyce B. J. van Meurs,Dominique J. Verlaan,Frances M K Williams,Andrew R. Wood,Yanhua Zhou,Kaare M. Gautvik,Tomi Pastinen,Soumya Raychaudhuri,Soumya Raychaudhuri,Jane A. Cauley,Daniel I. Chasman,Graeme R. Clark,Steven R. Cummings,Patrick Danoy,Elaine M. Dennison,Richard Eastell,John A. Eisman,John A. Eisman,Vilmundur Gudnason,Albert Hofman,Rebecca D. Jackson,Graeme Jones,J. Wouter Jukema,Kay-Tee Khaw,Terho Lehtimäki,Yongmei Liu,Mattias Lorentzon,Eugene V. McCloskey,Braxton D. Mitchell,Kannabiran Nandakumar,Geoffrey C. Nicholson,Ben A. Oostra,Munro Peacock,Huibert A. P. Pols,Richard L. Prince,Olli T. Raitakari,Olli T. Raitakari,Ian R. Reid,John A Robbins,Philip N. Sambrook,Pak C. Sham,Alan R. Shuldiner,Frances A. Tylavsky,Cornelia M. van Duijn,Nicholas J. Wareham,L. Adrienne Cupples,Michael J. Econs,David M. Evans,Tamara B. Harris,Annie W.C. Kung,Bruce M. Psaty,Jonathan Reeve,Tim D. Spector,Elizabeth A. Streeten,M. Carola Zillikens,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Claes Ohlsson,David Karasik,J. Brent Richards,Matthew A. Brown,Kari Stefansson,Kari Stefansson,André G. Uitterlinden,Stuart H. Ralston,John P. A. Ioannidis,John P. A. Ioannidis,Douglas P. Kiel,Fernando Rivadeneira +190 more
TL;DR: Light is shed on the genetic architecture and pathophysiological mechanisms underlying BMD variation and fracture susceptibility and within the RANK-RANKL-OPG, mesenchymal stem cell differentiation, endochondral ossification and Wnt signaling pathways.
Journal ArticleDOI
Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
Kenneth E. S. Poole,Rutger L. van Bezooijen,Nigel Loveridge,Herman Hamersma,Socrates E. Papapoulos,Clemens W.G.M. Löwik,Jonathan Reeve +6 more
TL;DR: In vivo evidence is provided for the first time to support the concept that osteocytes secrete sclerostin after they become embedded in a mineralized matrix to limit further bone formation by osteoblasts and propose that sclerOSTin production by osteocytes may regulate the linear extent of formation and the induction or maintenance of a lining cell phenotype on bone surfaces.
Journal ArticleDOI
A meta-analysis of prior corticosteroid use and fracture risk.
John A. Kanis,Helena Johansson,Anders Odén,Olof Johnell,Chris De Laet,L. Joseph Melton,Alan Tenenhouse,Jonathan Reeve,Alan J. Silman,Huibert A. P. Pols,John A. Eisman,Eugene V. McCloskey,Dan Mellström +12 more
TL;DR: The relationship between use of corticosteroids and fracture risk was estimated in a meta‐analysis of data from seven cohort studies of ∼42,000 men and women.