G
Gwyneth N. Lando
Researcher at Georgia Institute of Technology
Publications - 3
Citations - 208
Gwyneth N. Lando is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: Endothelial stem cell & Nucleic acid structure. The author has an hindex of 3, co-authored 3 publications receiving 106 citations.
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Journal ArticleDOI
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing.
Cory D. Sago,Melissa P. Lokugamage,Kalina Paunovska,Daryll Vanover,Christopher M. Monaco,Nirav N. Shah,Marielena Gamboa Castro,Shannon E. Anderson,Tobi G. Rudoltz,Gwyneth N. Lando,Pooja M. Tiwari,Jonathan L. Kirschman,Nick J. Willett,Young C. Jang,Philip J. Santangelo,Anton V. Bryksin,James E. Dahlman +16 more
TL;DR: A high-throughput method to measure how >100 nanoparticles delivered mRNA that was translated into functional protein in vivo and identify 7C2 and 7C3, two LNPs that efficiently deliver siRNA, single-guide RNA (sgRNA), and mRNA to endothelial cells.
Journal ArticleDOI
Modifying a Commonly Expressed Endocytic Receptor Retargets Nanoparticles in Vivo
Cory D. Sago,Melissa P. Lokugamage,Gwyneth N. Lando,Naima Djeddar,Nirav N. Shah,Christopher K. Syed,Anton V. Bryksin,James E. Dahlman +7 more
TL;DR: Cav1 altered delivery in a cell-type specific manner, and data suggest caveolin-mediated endocytosis of nanomedicines by macrophages varies with tissue type, suggest manipulating receptors expressed on multiple cell types can tune drug delivery.
Journal ArticleDOI
Barcoding chemical modifications into nucleic acids improves drug stability in vivo
Cory D. Sago,Sujay Kalathoor,Jordan P. Fitzgerald,Gwyneth N. Lando,Naima Djeddar,Anton V. Bryksin,James E. Dahlman +6 more
TL;DR: The efficacy of nucleic acid therapies can be limited by unwanted degradation, and the use of these therapies should not be considered as a substitute for conventional therapies.