M
Marielena Gamboa Castro
Researcher at Georgia Institute of Technology
Publications - 3
Citations - 350
Marielena Gamboa Castro is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: In vivo & Endothelial stem cell. The author has an hindex of 3, co-authored 3 publications receiving 177 citations.
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Journal ArticleDOI
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing.
Cory D. Sago,Melissa P. Lokugamage,Kalina Paunovska,Daryll Vanover,Christopher M. Monaco,Nirav N. Shah,Marielena Gamboa Castro,Shannon E. Anderson,Tobi G. Rudoltz,Gwyneth N. Lando,Pooja M. Tiwari,Jonathan L. Kirschman,Nick J. Willett,Young C. Jang,Philip J. Santangelo,Anton V. Bryksin,James E. Dahlman +16 more
TL;DR: A high-throughput method to measure how >100 nanoparticles delivered mRNA that was translated into functional protein in vivo and identify 7C2 and 7C3, two LNPs that efficiently deliver siRNA, single-guide RNA (sgRNA), and mRNA to endothelial cells.
Journal ArticleDOI
A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation.
Kalina Paunovska,Cory D. Sago,Christopher M. Monaco,William H. Hudson,Marielena Gamboa Castro,Tobi G. Rudoltz,Sujay Kalathoor,Daryll Vanover,Philip J. Santangelo,Rafi Ahmed,Anton V. Bryksin,James E. Dahlman +11 more
TL;DR: Using high throughput LNP barcoding, data demonstrate that barcoded LNPs can elucidate fundamental questions about in vivo nanoparticle delivery and does LNP delivery change within the microenvironment of a tissue.
Journal ArticleDOI
Analyzing 2000 in Vivo Drug Delivery Data Points Reveals Cholesterol Structure Impacts Nanoparticle Delivery
Kalina Paunovska,Carmen J. Gil,Melissa P. Lokugamage,Cory D. Sago,Manaka Sato,Gwyn N. Lando,Marielena Gamboa Castro,Anton V. Bryksin,James E. Dahlman +8 more
TL;DR: Lipid nanoparticles formulated with esterified cholesterol delivered nucleic acids more efficiently than LNPs formulated with regular or oxidized cholesterol when compared across all tested cell types in the mouse, and an LNP containing cholesteryl oleate was identified that efficiently delivered siRNA and sgRNA to liver endothelial cells in vivo.