D
Daryll Vanover
Researcher at Georgia Institute of Technology
Publications - 31
Citations - 1048
Daryll Vanover is an academic researcher from Georgia Institute of Technology. The author has contributed to research in topics: RNA & Messenger RNA. The author has an hindex of 12, co-authored 26 publications receiving 563 citations. Previous affiliations of Daryll Vanover include Duke University.
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Journal ArticleDOI
High-throughput in vivo screen of functional mRNA delivery identifies nanoparticles for endothelial cell gene editing.
Cory D. Sago,Melissa P. Lokugamage,Kalina Paunovska,Daryll Vanover,Christopher M. Monaco,Nirav N. Shah,Marielena Gamboa Castro,Shannon E. Anderson,Tobi G. Rudoltz,Gwyneth N. Lando,Pooja M. Tiwari,Jonathan L. Kirschman,Nick J. Willett,Young C. Jang,Philip J. Santangelo,Anton V. Bryksin,James E. Dahlman +16 more
TL;DR: A high-throughput method to measure how >100 nanoparticles delivered mRNA that was translated into functional protein in vivo and identify 7C2 and 7C3, two LNPs that efficiently deliver siRNA, single-guide RNA (sgRNA), and mRNA to endothelial cells.
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A Direct Comparison of in Vitro and in Vivo Nucleic Acid Delivery Mediated by Hundreds of Nanoparticles Reveals a Weak Correlation.
Kalina Paunovska,Cory D. Sago,Christopher M. Monaco,William H. Hudson,Marielena Gamboa Castro,Tobi G. Rudoltz,Sujay Kalathoor,Daryll Vanover,Philip J. Santangelo,Rafi Ahmed,Anton V. Bryksin,James E. Dahlman +11 more
TL;DR: Using high throughput LNP barcoding, data demonstrate that barcoded LNPs can elucidate fundamental questions about in vivo nanoparticle delivery and does LNP delivery change within the microenvironment of a tissue.
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Structural Analysis of Respiratory Syncytial Virus Reveals the Position of M2-1 between the Matrix Protein and the Ribonucleoprotein Complex
Gabriella Kiss,Jens M. Holl,G Williams,Eric Alonas,Daryll Vanover,Aaron W. Lifland,Manasa Gudheti,Ricardo C. Guerrero-Ferreira,Vinod Nair,Hong Yi,Barney S. Graham,Philip J. Santangelo,Elizabeth R. Wright +12 more
TL;DR: Cryo-electron tomography studies provide a more complete characterization of the hRSV virion structure and substantiation that M and M2-1 regulate virus organization.
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Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents.
Emmeline L. Blanchard,Daryll Vanover,Swapnil Bawage,Pooja M. Tiwari,Laura Rotolo,Jared Beyersdorf,Hannah E. Peck,Nicholas C. Bruno,Robert Hincapie,Frank Michel,Jackelyn Murray,Heena Sadhwani,Bob Vanderheyden,M. G. Finn,Margo A. Brinton,Eric R. Lafontaine,Robert J. Hogan,Chiara Zurla,Philip J. Santangelo +18 more
TL;DR: In this paper, the authors used RNA-encoded Cas13a for mitigating influenza virus A and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in mice and hamsters, respectively.
Journal ArticleDOI
Arginine-Rich Peptide-Based mRNA Nanocomplexes Efficiently Instigate Cytotoxic T Cell Immunity Dependent on the Amphipathic Organization of the Peptide
Vimal Kumar Udhayakumar,Ans De Beuckelaer,Joanne McCaffrey,Cian M. McCrudden,Jonathan L. Kirschman,Daryll Vanover,Lien Van Hoecke,Kenny Roose,Kim Deswarte,Bruno G. De Geest,Stefan Lienenklaus,Philip J. Santangelo,Johan Grooten,Helen O. McCarthy,Stefaan De Koker +14 more
TL;DR: The potential of a cell‐penetrating peptide containing the amphipathic RALA motif to deliver antigen‐encoding mRNA to the immune system to elicit potent cytolytic T cell responses against the antigenic mRNA cargo is described.