H. Dariush Fahimi

TL;DR: The role of PPARalpha, which is highly activated in PEX5-/- mice with the absence of functional peroxisomes severe abnormalities of mitochondria in different organs are observed which resemble closely those in respiratory chain disorders associated with oxidative stress.

TL;DR: This review intends to highlight recent discoveries, advancements and trends in peroxisome research, and present an update as well as a continuation of two former review articles addressing the unsolved mysteries of this astonishing organelle.

TL;DR: Novel findings concerning the relationship between ROS and peroxisomes are discussed, as they revealed to be a key player in the dynamic spin of ROS metabolism and oxidative injury.

TL;DR: It is demonstrated that osmium-imidazole provides an excellent stain for lipids in transmission electron microscopy and that most probably it stains lipids with unsaturated fatty acids.

TL;DR: Evidence is presented that the absence of functional peroxisomes, causing a general defect inPeroxisomal metabolism, leads to proliferation of pleomorphic mitochondria with severe alterations of the mitochondrial ultrastructure, changes in the expression and activities of mitochondrial respiratory chain complexes, and an increase in the heterogeneity of the mitochondria compartment in various organs and specific cell types.