M
Marcel Borgers
Researcher at Maastricht University
Publications - 189
Citations - 11325
Marcel Borgers is an academic researcher from Maastricht University. The author has contributed to research in topics: Hibernating myocardium & Myocyte. The author has an hindex of 54, co-authored 188 publications receiving 11000 citations. Previous affiliations of Marcel Borgers include Johnson & Johnson & Princeton University.
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Journal ArticleDOI
Inhibition of plasminogen activators or matrix metalloproteinases prevents cardiac rupture but impairs therapeutic angiogenesis and causes cardiac failure.
Stephane Heymans,Aernout Luttun,Dieter Nuyens,Gregor Theilmeier,Esther E. Creemers,Lieve Moons,G D Dyspersin,Jack P.M. Cleutjens,M Shipley,A Angellilo,Marcel Levi,O Nübe,Andrew Baker,Eli Keshet,Florea Lupu,Jean-Marc Herbert,Jos F.M. Smits,Steven D. Shapiro,Myriam Baes,Marcel Borgers,Desire Collen,Mat J.A.P. Daemen,Peter Carmeliet +22 more
TL;DR: Temporary administration of PA inhibitor-1 or the matrix metalloproteinase-inhibitor TIMP-1 completely protected wild-type mice against rupture but did not abort infarct healing, thus constituting a new approach to prevent cardiac rupture after acute myocardial infarction.
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Accumulation of Ultrasmall Superparamagnetic Particles of Iron Oxide in Human Atherosclerotic Plaques Can Be Detected by In Vivo Magnetic Resonance Imaging
ME Marianne Eline Kooi,Vincent C. Cappendijk,Kbjm Cleutjens,Agh Alphons Kessels,Peter J.E.H.M. Kitslaar,Marcel Borgers,Peter M. Frederik,M. Daemen,van Jma Jos Engelshoven +8 more
TL;DR: Accumulation of USPIOs in macrophages in predominantly ruptured and rupture-prone human atherosclerotic lesions caused signal decreases in the in vivo MR images.
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Structural Changes of Atrial Myocardium due to Sustained Atrial Fibrillation in the Goat
Jannie Ausma,Maurits C.E.F. Wijffels,Fred Thoné,Luc Wouters,Maurits A. Allessie,Marcel Borgers +5 more
TL;DR: This goat model of AF offers a new approach to study the cascade of events leading to sustained AF and its maintenance, and leads to predominantly structural changes in the atrial myocytes similar to those seen in ventricular myocytes from chronic hibernating myocardium.
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Mechanisms of chronic regional postischemic dysfunction in humans. New insights from the study of noninfarcted collateral-dependent myocardium.
Jean-Louis Vanoverschelde,William Wijns,Christophe Depre,B. Essamri,Guy R. Heyndrickx,Marcel Borgers,Anne Bol,Jacques Melin +7 more
TL;DR: A subgroup of patients with noninfarcted collateral-dependent myocardium, immature or insufficiently developed collaterals do not provide adequate flow reserve and it is proposed that these alterations result from repeated episodes of ischemia as opposed to chronic hypoperfusion.
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Contribution of mutations in the cytochrome P450 14α-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans
Patrick Marichal,Patrick Marichal,Luc Koymans,Staf Willemsens,D. Bellens,Peter Verhasselt,Walter Luyten,Marcel Borgers,Frans C. S. Ramaekers,Frank C. Odds,Hugo Vanden Bossche +10 more
TL;DR: The cytochrome P450 14alpha-demethylase, encoded by the ERG11 (CYP51) gene, is the primary target for the azole class of antifungals and mutations found in the two N-terminal regions only Y132H was demonstrated to be of importance for azole resistance.