H
H Fred Clark
Researcher at Children's Hospital of Philadelphia
Publications - 48
Citations - 3855
H Fred Clark is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Rotavirus & Rotavirus vaccine. The author has an hindex of 24, co-authored 48 publications receiving 3771 citations. Previous affiliations of H Fred Clark include Wistar Institute & University of Pennsylvania.
Papers
More filters
Journal ArticleDOI
Safety and Efficacy of a Pentavalent Human–Bovine (WC3) Reassortant Rotavirus Vaccine
Timo Vesikari,David O. Matson,Penelope H. Dennehy,Pierre Van Damme,Mathuram Santosham,Zoe M. Rodriguez,Michael J. Dallas,Joseph F. Heyse,Michelle G. Goveia,Steven Black,Henry R. Shinefield,Celia D. C. Christie,Samuli Ylitalo,Robbin F. Itzler,Michele L. Coia,Matthew T. Onorato,Ben A. Adeyi,Gary S. Marshall,Leif Gothefors,Dirk Campens,Aino Karvonen,James P. Watt,Katherine L. O'Brien,Mark J. DiNubile,H Fred Clark,John W. Boslego,Paul A. Offit,Penny M. Heaton +27 more
TL;DR: This vaccine was efficacious in preventing rotavirus gastroenteritis, decreasing severe disease and health care contacts, and the risk of intussusception was similar in vaccine and placebo recipients.
Journal ArticleDOI
A dialysis technique for preparing fluorescent antibody.
H Fred Clark,Charles C. Shepard +1 more
Journal ArticleDOI
Group A rotaviruses produce extrahepatic biliary obstruction in orally inoculated newborn mice.
Marie Riepenhoff-Talty,Marie Riepenhoff-Talty,Knut Schaekel,H Fred Clark,Wolfgang Mueller,Ingrid Uhnoo,Thomas M. Rossi,John E. Fisher,Pearay L. Ogra +8 more
TL;DR: Although there was no obvious atresia as described in human infants, the obstruction in immunocompetent BALB/c infant mice infected with a human or animal strain of group A rotavirus was strikingly similar to those seen in the liver of the human infant with biliary atResia.
Journal ArticleDOI
Safety, efficacy, and immunogenicity of a live, quadrivalent human-bovine reassortant rotavirus vaccine in healthy infants
H Fred Clark,David I. Bernstein,Penelope H. Dennehy,Paul A. Offit,Michael E. Pichichero,John J. Treanor,Richard L. Ward,David L. Krah,Alan Shaw,Michael J. Dallas,Digilio Laura,Joseph J. Eiden,Nathalie Ivanoff,Karen M. Kaplan,Penny Heaton +14 more
TL;DR: QRV was generally well tolerated, immungenic, and highly effective against rotavirus gastroenteritis; no serious vaccine-related adverse experiences were reported.
Journal ArticleDOI
Effects of the potency and composition of the multivalent human-bovine (WC3) reassortant rotavirus vaccine on efficacy, safety and immunogenicity in healthy infants.
Timo Vesikari,H Fred Clark,Paul A. Offit,Michael J. Dallas,Daniel J. DiStefano,Michelle G. Goveia,Richard L. Ward,Florian Schödel,Aino Karvonen,James E. Drummond,Mark J. DiNubile,Penny M. Heaton +11 more
TL;DR: Based on the results of this trial, a pentavalent composition (G1, G2, G3, G4, and P1A) of human-bovine (WC3) reassortant rotavirus vaccine with a potency similar to that of the middle-potencypentavalent vaccine was selected for further development.