Journal ArticleDOI
Safety and Efficacy of a Pentavalent Human–Bovine (WC3) Reassortant Rotavirus Vaccine
Timo Vesikari,David O. Matson,Penelope H. Dennehy,Pierre Van Damme,Mathuram Santosham,Zoe M. Rodriguez,Michael J. Dallas,Joseph F. Heyse,Michelle G. Goveia,Steven Black,Henry R. Shinefield,Celia D. C. Christie,Samuli Ylitalo,Robbin F. Itzler,Michele L. Coia,Matthew T. Onorato,Ben A. Adeyi,Gary S. Marshall,Leif Gothefors,Dirk Campens,Aino Karvonen,James P. Watt,Katherine L. O'Brien,Mark J. DiNubile,H Fred Clark,John W. Boslego,Paul A. Offit,Penny M. Heaton +27 more
TLDR
This vaccine was efficacious in preventing rotavirus gastroenteritis, decreasing severe disease and health care contacts, and the risk of intussusception was similar in vaccine and placebo recipients.Abstract:
BACKGROUND: Rotavirus is a leading cause of childhood gastroenteritis and death worldwide. METHODS: We studied healthy infants approximately 6 to 12 weeks old who were randomly assigned to receive ...read more
Citations
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Journal Article
Prevention of rotavirus gastroenteritis among infants and children. Recommendations of the Advisory Committee on Immunization Practices (ACIP).
TL;DR: The Advisory Committee on Immunization Practices recommends routine vaccination of U.S. infants with 3 doses of this rotavirus vaccine administered orally at ages 2, 4, and 6 months.
Journal ArticleDOI
2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis
Jacqueline E. Tate,Anthony H. Burton,Cynthia Boschi-Pinto,A. Duncan Steele,Jazmin Duque,Umesh D. Parashar +5 more
TL;DR: The estimated number of deaths worldwide in children younger than 5 years due to diarrhoea attributable to rotavirus infection is updated to help advocate for rotav virus vaccine introduction and to monitor the effect of vaccination on mortality once introduced.
Advisory Committee on Immunization Practices (ACIP), Centers for Disease Control and Prevention (CDC) : Prevention of rotavirus gastroenteritis among infants and children. Recommendations of the Advisory Committee on Immunization Practices (ACIP)
TL;DR: This report updates and replaces the 2006 ACIP statement for prevention of rotavirus gastroenteritis and addresses the maximum ages for doses, contraindications, precautions, and special situations for the administration of rotvirus vaccine.
Journal ArticleDOI
Global, Regional, and National Estimates of Rotavirus Mortality in Children <5 Years of Age, 2000-2013.
TL;DR: While rotvirus vaccine had been introduced in >60 countries worldwide by the end of 2013, the majority of countries using rotavirus vaccine during the review period were low-mortality countries and the impact of rotav virus vaccine on global estimates of rotovirus mortality has been limited.
Journal ArticleDOI
Effect of human rotavirus vaccine on severe diarrhea in African infants.
Shabir A. Madhi,Nigel A. Cunliffe,Duncan Steele,Desiree Witte,Mari Kirsten,Cheryl Louw,Bagrey Ngwira,John C. Victor,Paul Gillard,Brigitte Cheuvart,Htay Htay Han,Kathleen M. Neuzil +11 more
TL;DR: Human rotvirus vaccine significantly reduced the incidence of severe rotavirus gastroenteritis among African infants during the first year of life.
References
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Journal ArticleDOI
Global Illness and Deaths Caused by Rotavirus Disease in Children
TL;DR: The tremendous incidence of rotavirus disease underscores the urgent need for interventions, such as vaccines, to prevent childhood deaths in developing nations.
Journal ArticleDOI
Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine.
Norma Santos,Yasutaka Hoshino +1 more
TL;DR: The temporal and geographical distribution of human rotavirus G and P types was reviewed by analysing a total of 45571 strains collected globally from 124 studies reported from 52 countries on five continents published between 1989 and 2004 and revealed several characteristic features.
Book
Group Sequential Methods with Applications to Clinical Trials
TL;DR: A short history of sequential and group sequential methods can be found in this paper, where the authors present a road map for the application of two-sided tests for comparing two treatments with normal response of known variance.
Journal ArticleDOI
Intussusception among infants given an oral rotavirus vaccine.
Trudy V. Murphy,Paul Gargiullo,Mehran S. Massoudi,David B. Nelson,Aisha O. Jumaan,Catherine A. Okoro,Lynn R. Zanardi,Sabeena Setia,Elizabeth Fair,Charles W. LeBaron,Benjamin Schwartz,Melinda Wharton,John R. Livingood +12 more
TL;DR: The strong association between vaccination with RRV-TV and intussusception among otherwise healthy infants supports the existence of a causal relation.
Journal ArticleDOI
Rotavirus Infection in Infants as Protection against Subsequent Infections
F R Velázquez,David O. Matson,Juan J. Calva,Guerrero L,Ardythe L. Morrow,S Carter-Campbell,Roger I. Glass,Mary K. Estes,Larry K. Pickering,Guillermo M. Ruiz-Palacios +9 more
TL;DR: In infants, natural rotavirus infection confers protection against subsequent infection, which increases with each new infection and reduces the severity of the diarrhea.
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Global distribution of rotavirus serotypes/genotypes and its implication for the development and implementation of an effective rotavirus vaccine.
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