Palladium-catalyzed alkynylation.

Part 1 Modern computational and theoretical aspects of acetylene chemistry, Dietmar A. Plattner et al: electronic structures of acetylene and monoacetylenes reactivities and molecular interactions of acetylenes polyacetylenes. Part 2 Functionalized acetylenes in organic synthesis - the cases of the 1-cyano- and the 1-halogenacetylenes, Henning Hopf and Bernhard Witulski: synthesis and preparative use of cyanoacetylenes synthesis and preparative use of 1-halogenacetylenes experimental procedures. Part 3 Alkynyliodonium salts - electrophilic acetylene equivalents, Peter J. Stang: preparation and properties characterization and structure reactions and uses of alkynyliodonium salts experimental procedures. Part 4 The chemistry of metal-alkyne complexes, Gagik G. Melikyan and Kenneth M. Nicholas: bonding and structure complexes of novel alkynes reactions of metal-alkyne complexes special applications of metal-alkyne complexes selected experimental procedures. Part 5 Organometallic cycloaddition reactions of acetylenes, Joseph A. Casalnuovo and Neil E. Schore: cycloadditions of acetylenes with Fischer carbenes the Pauson-Khand reaction - cycloadditions of olefins, acetylenes and CO. Part 6 Phosphaalkynes - starting point for the synthesis of phosphorous-carbon cage compounds, Manfred Regitz et al: syntheses of phosphaalkynes reactivity of phosphaalkynes the history of phosphorous-carbon cage compounds from phosphaalkynes synthesis of phosphorous-carbon cage compounds outlook experimental procedures. Part 7 The enediyne antibiotics, K.C. Nicolaou and Adrian L. Smith: the aromaticity era the discovery of the enediyne antibiotics theoretical and synthetic studies on the enediyne antibiotics medical applications of the enediyne antibiotics. Part 8 Cyclic alkynes - preparation and properties, Rolf Gleiter and Roland Merger: synthesis of cyclic acetylenes structural and spectroscopic properties organic reactions of cyclic alkynes reactions of cyclic alkynes with metal compounds experimental procedures. Part 9 Macrocyclic homoconjugated polyacetylenes, Lawrence T. Scott and Mark J. Cooney: pericyclynes "exploded" pericyclynes homoconjugated mixed polyalkyne/diyne macrocycles heterocyclic cognates of pericyclynes experimental procedures. Part 10 Polyacetylene, Eric J. Ginsburg et al: syntheses and properties. Part 11 Acetylenic compounds as building blocks for high-spin molecules and molecular assemblies, Hiizu Iwamura and Kenji Matsuda: alkynyl compounds carrying unpaired electrons molecular crystals of organic free radicals that carry alkynyl substituents spin alignments in poly(phenylacetylenes) and poly(1,3-butadiynes) cyclotrimerization reaction of benzoylacetylenes in the presence of a secondary amine experimental procedures. Part 12 Acetylenes in nanostructures, James K. Young and Jeffrey S. Moore: phenylacetylene dendrimers phenylacetylene macrocycles synthesis of sequence-(Part contents)

Modern acetylene chemistry

Intramolecular 1,3-dipolar cycloaddition reactions in targeted syntheses

The Chemistry of Enediynes, Enyne Allenes and Related Compounds

The field of carbohydrate chemistry has occupied the minds and hearts of many scientists for over a hundred years and, as we enter the twenty-first century, it continues to be both vigorous and challenging. Among the most exciting aspects of organic chemistry in the last few decades has been the interplay between the specialized subdisciplines of carbohydrate chemistry and total synthesis, each enabling and advancing the other in new directions and towards greater heights. In this review article we highlight our own adventures at the interface of these disciplines, which were driven for the most part by objectives in chemical synthesis and chemical biology. Specifically, we describe our interests and efforts to utilize carbohydrates as starting materials for total synthesis, to invent and develop new synthetic technologies for carbohydrate synthesis, to construct complex oligosaccharides in solution or on solid support, and to utilize carbohydrate templates as scaffolds for peptide mimetics and for molecular diversity construction. Finally, applications of the developed synthetic strategies and enabling technologies towards the solution of biologically significant problems are discussed.

Adventures in Carbohydrate Chemistry: New Synthetic Technologies, Chemical Synthesis, Molecular Design, and Chemical Biology

Total synthesis of calicheamicin .gamma.1I

The first enantioselective total synthesis of (-)-calicheamicinone (3), the naturally occurring antipode of the calicheamicin aglycon, has been achieved

H. Saimoto

Papers

Total synthesis of calicheamicin .gamma.1I

Total synthesis of calicheamicin .gamma.1I. 2. Development of an enantioselective route to (-)-calicheamicinone

Synthetic calicheamicin mimics with novel initiation mechanisms: DNA cleavage, cytotoxicity, and apoptosis