C
C.-K. Hwang
Researcher at Scripps Research Institute
Publications - 23
Citations - 677
C.-K. Hwang is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Ring (chemistry) & Total synthesis. The author has an hindex of 8, co-authored 23 publications receiving 667 citations.
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Journal ArticleDOI
Total Synthesis of Taxol. 2. Construction of A and C Ring Intermediates and Initial Attempts To Construct the ABC Ring System
Kyriacos C. Nicolaou,Jia Liu,Zhen Yang,H. Ueno,Erik J. Sorensen,Christopher F. Claiborne,R. K. Guy,C.-K. Hwang,Masahisa Nakada,P. G. Nantermet +9 more
Journal ArticleDOI
Total synthesis of hemibrevetoxin B and (7a.alpha.)-epi-hemibrevetoxin B
TL;DR: The total synthesis of hemibrevetoxin B (1) and (7aα)-epi-hemibrevoxin B(2) is described in this article, where the α-vinyl functionality was installed using the Eschenmoser's salt methodology.
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Total synthesis of calicheamicin .gamma.1I. 2. Development of an enantioselective route to (-)-calicheamicinone
Adrian L. Smith,Emmanuel N. Pitsinos,C.-K. Hwang,Y. Mizuno,H. Saimoto,G. R. Scarlato,Toshio Suzuki,Kyriacos C. Nicolaou +7 more
TL;DR: The first enantioselective total synthesis of (-)-calicheamicinone (3), the naturally occurring antipode of the calicheamin aglycon, has been achieved as discussed by the authors.
Journal ArticleDOI
Total Synthesis of Brevetoxin-B .2. 2nd Generation Strategies and Construction of the Dioxepane Region [Defg]
Kyriacos C. Nicolaou,Emmanuel A. Theodorakis,Floris P. J. T. Rutjes,M. Sato,J. Tiebes,X.‐Y. Xiao,C.-K. Hwang,M. E. Duggan,Zhen Yang,Elias A. Couladouros,F. Sato,Jongheon Shin,H.‐M. He,T. Bleckman +13 more
TL;DR: The second generation strategy for the total synthesis of brevetoxin B (1) is presented in this paper, where the Yamaguchi lactonization was successfully applied for the formation of the EFG and (DEFG) lactones (15 -* 7) and (29 6), respectively.