Hao Liu

TL;DR: Losartan reduces solid stress in tumours resulting in increased vascular perfusion, thereby potentiating chemotherapy and reducing hypoxia in breast and pancreatic cancer models, suggesting that angiotensin inhibitors —inexpensive drugs with decades of safe use — could be rapidly repurposed as cancer therapeutics.

TL;DR: In this paper, the angiotensin inhibitor losartan reduces stromal collagen and hyaluronan production, associated with decreased expression of profibrotic signals TGF-β1, CCN2 and ET-1.

TL;DR: It is concluded that cross-talk between adipocytes, TANs, and PSCs exacerbates desmoplasia and promotes tumor progression in obesity and that clinically available antifibrotic/inflammatory agents can improve the treatment response of PDAC in obese hosts.

TL;DR: Two-dimensional spatial mappings of solid stress and the resulting elastic energy in excised or in situ tumours with arbitrary shapes and wide size ranges can be obtained via three distinct and quantitative techniques that rely on the measurement of tissue displacement after disruption of the confining structures.

TL;DR: An artificial composite protective layer consisting of nano-sized metal-organic frameworks (MOFs) to improve the poor wetting effect of aqueous electrolytes on Zn anode, is proposed to reconstruct the Zn/electrolyte interface to demonstrate an effective way to reconstruct a stable interface on metal anodes (e.g. Zn) where a conventional solid-electrolies interface (SEI) cannot be formed.