H
Haemin Hong
Researcher at University of California, San Francisco
Publications - 3
Citations - 694
Haemin Hong is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Thermogenin & Phosphorylation. The author has an hindex of 3, co-authored 3 publications receiving 554 citations.
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Journal ArticleDOI
Genetic and functional characterization of clonally derived adult human brown adipocytes
Kosaku Shinoda,Ineke H.N. Luijten,Yutaka Hasegawa,Haemin Hong,Si Brask Sonne,Miae Kim,Ruidan Xue,Maria Chondronikola,Aaron M. Cypess,Yu-Hua Tseng,Jan Nedergaard,Labros S. Sidossis,Shingo Kajimura +12 more
TL;DR: This study isolated clonally derived adipocytes from stromal vascular fractions of adult human BAT from two individuals and globally analyzed their molecular signatures and found that KCNK3 and MTUS1 were required for beige adipocyte differentiation and thermogenic function.
Journal ArticleDOI
Beige Adipocyte Maintenance Is Regulated by Autophagy-Induced Mitochondrial Clearance
Svetlana Altshuler-Keylin,Kosaku Shinoda,Yutaka Hasegawa,Kenji Ikeda,Haemin Hong,Qianqian Kang,Yangyu Yang,Rushika M. Perera,Jayanta Debnath,Shingo Kajimura +9 more
TL;DR: It is demonstrated that beige adipocytes progressively lose their morphological and molecular characteristics after withdrawing external stimuli and directly acquire white-like characteristics bypassing an intermediate precursor stage, uncovers a fundamental mechanism by which autophagy-mediated mitochondrial clearance controls bege adipocyte maintenance, thereby providing new opportunities to counteract obesity.
Journal ArticleDOI
Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure
Kosaku Shinoda,Kana Ohyama,Yutaka Hasegawa,Hsin Yi Chang,Mayu Ogura,Ayaka Sato,Haemin Hong,Takashi Hosono,Louis Z. Sharp,David W. Scheel,Mark J. Graham,Yasushi Ishihama,Shingo Kajimura +12 more
TL;DR: It is found that casein kinase2 (CK2) activity is preferentially higher in white adipocytes than brown/beige adipocytes, and this results indicate that CK2 is a plausible target to rewire the β3-adrenenoceptor signaling cascade that promotes thermogenesis in adipocytes.