Y
Yu-Hua Tseng
Researcher at Harvard University
Publications - 161
Citations - 18003
Yu-Hua Tseng is an academic researcher from Harvard University. The author has contributed to research in topics: Adipose tissue & Brown adipose tissue. The author has an hindex of 50, co-authored 128 publications receiving 15204 citations. Previous affiliations of Yu-Hua Tseng include University of Connecticut & Joslin Diabetes Center.
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Journal ArticleDOI
Identification and Importance of Brown Adipose Tissue in Adult Humans
AM Cypess,Sanaz Lehman,Gethin Williams,Ilan Tal,Dean Rodman,Allison B. Goldfine,FC Kuo,Edwin L. Palmer,Yu-Hua Tseng,Alessandro Doria,Gerald M. Kolodny,C R Kahn +11 more
TL;DR: Defined regions of functionally active brown adipose tissue are present in adult humans, are more frequent in women than in men, and may be quantified noninvasively with the use of (18)F-FDG PET-CT.
Journal ArticleDOI
Developmental Origin of Fat: Tracking Obesity to Its Source
TL;DR: This Review considers how the developmental origins of fat contribute to its physiological, cellular, and molecular heterogeneity and explores how these factors may play a role in the growing epidemic of obesity.
Journal ArticleDOI
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
Yu-Hua Tseng,Efi Kokkotou,Tim J. Schulz,Tian Lian Huang,Jonathon N. Winnay,Cullen M. Taniguchi,Thien T. Tran,Ryo Suzuki,Daniel Espinoza,Yuji Yamamoto,Molly J. Ahrens,Andrew T. Dudley,Andrew W. Norris,Rohit N. Kulkarni,C. Ronald Kahn +14 more
TL;DR: It is demonstrated that whereas some members of the family of bone morphogenetic proteins (BMPs) support white adipocyte differentiation, BMP7 singularly promotes differentiation of brown preadipocytes even in the absence of the normally required hormonal induction cocktail.
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Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
Kristin I. Stanford,Roeland J.W. Middelbeek,Kristy L. Townsend,Ding An,Eva B. Nygaard,Kristen M. Hitchcox,Kathleen R. Markan,Kazuhiro Nakano,Michael F. Hirshman,Yu-Hua Tseng,Laurie J. Goodyear +10 more
TL;DR: A previously under-appreciated role for BAT in glucose metabolism is revealed, demonstrating that BAT-derived IL-6 is required for the profound effects of BAT transplantation on glucose homeostasis and insulin sensitivity.
Journal ArticleDOI
Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
Aaron M. Cypess,Andrew P. White,Cecile Vernochet,Tim J. Schulz,Ruidan Xue,Christina A. Sass,Tian Liang Huang,Carla Roberts-Toler,Lauren S Weiner,Cathy Sze,Aron T. Chacko,Laura N. Deschamps,Lindsay M Herder,Nathan Truchan,Allison L Glasgow,Ashley R. Holman,Alina Gavrila,Per-Olof Hasselgren,Marcelo A. Mori,Michael Molla,Yu-Hua Tseng +20 more
TL;DR: This study isolated anatomically defined neck fat from adult human volunteers and compared its gene expression, differentiation capacity and basal oxygen consumption to different mouse adipose depots, suggesting that activation of human BAT could be used as a safe treatment for obesity and metabolic dysregulation.