Haida Teng

TL;DR: Ten previously undescribed compounds, including five prenylated xanthones, two caged xanthone bearing a rare 8, 8a-epoxy moiety and three rearranged benzophenones, together with nineteen known compounds were isolated from the fruits of Garcinia bracteata to enrich the structural diversities ofxanthones and Benzophenones from Garcinia plants.

TL;DR: The findings enrich and improve the research on the structural diversity and biological activity of sulphur-containing amides and provide phytochemical and pharmacological evidence for the further development and utilization of the leaves of G. pentaphylla in pharmaceutical industry.

TL;DR: Five new homoadamantane polycyclic polyprenylated acylphloroglucinols (PPAPs, 1-5) were isolated from the fruits of Garcinia multiflora by extensive spectroscopic analyses including NMR, HRESIMS and electronic circular dichroism (ECD).

Abstract: Nine undescribed caged polycyclic polyprenylated acylphloroglucinols (PPAPs), including adamantane type PPAPs (1–2), and homoadamantane type PPAPs (3–9), were isolated from the fruits of Garcinia multiflora, along with three known analogues. A new epimeric pair of isohypersampsonone B (5) and epi-isohypersampsonone B (6), featuring an unusual hexahydrofuro[2,3-b]furan-diepoxy ring system fused in a homoadamantane skeleton, was not separated due to the rapid equilibration between the two isomeric forms. All new caged PPAPs (1–9), sharing a common isogeranyl group, were determined on the basis of comprehensive NMR and MS spectroscopic data. Their cytotoxicity against three human tumor cell lines (SGC-7901, HepG2, HCT-116) and the nitric oxide production inhibitory activity of lipopolysaccharides-stimulated RAW 264.7 cells were tested. Compounds 8 and 12 displayed mild cytotoxicity against three human cancer cell lines with IC50 values of 10–20 μM. Furthermore, compounds 8 and 12 also exhibited NO production inhibitory effect with an IC50 value of 18.24 and 12.50 μM respectively.

TL;DR: Two novel polycyclic polyprenylated acylphloroglucinols (PPAPs) and garcibractinones A and B were isolated from Garcinia bracteata fruits and possess an unprecedented caged tricyclo- [4.4.1.11,4] dodecane skeleton.