K
Kounosuke Watabe
Researcher at Wake Forest University
Publications - 179
Citations - 11680
Kounosuke Watabe is an academic researcher from Wake Forest University. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 53, co-authored 161 publications receiving 9728 citations. Previous affiliations of Kounosuke Watabe include Wake Forest Baptist Medical Center & Southern Illinois University School of Medicine.
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Journal ArticleDOI
p53 represses c-Myc through induction of the tumor suppressor miR-145
Mohit Sachdeva,Shoumin Zhu,Fangting Wu,Hailong Wu,Vijay Walia,Sumit Kumar,Randolph C. Elble,Kounosuke Watabe,Yin-Yuan Mo +8 more
TL;DR: The role of miR-145 is defined in the posttranscriptional regulation of c-Myc by p53 and it is suggested that, as a new member of the p53 regulatory network, mi R-145 provides a direct link between p 53 and c- myc in this gene regulatory network.
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Cancer associated fibroblasts (CAFs) in tumor microenvironment.
TL;DR: The latest findings on the role of CAFs in tumorigenesis and metastasis as well as potential therapeutic implication ofCAFs are discussed.
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Negative regulation of lncRNA GAS5 by miR-21
TL;DR: Results suggest that miR-21 targets not only tumor-suppressive protein-coding genes but also lncRNA GAS5, and may regulate each other in a way similar to the microRNA-mediated silencing of target mRNAs.
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Fatty Acid Synthase Gene Is Up-regulated by Hypoxia via Activation of Akt and Sterol Regulatory Element Binding Protein-1
Eiji Furuta,Sudha K. Pai,Rui Zhan,Sucharita Bandyopadhyay,Misako Watabe,Yin-Yuan Mo,Shigeru Hirota,Sadahiro Hosobe,Taisei Tsukada,Kunio Miura,Shuichi Kamada,Ken Saito,Megumi Iiizumi,Wen Liu,Johan Ericsson,Kounosuke Watabe +15 more
TL;DR: The results indicate that FAS gene is up-regulated by hypoxia via activation of the Akt and HIF1 followed by the induction of the SREBP-1 gene, and that Hypoxia-induced chemoresistance is partly due to the up-regulation of FAS.
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Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
Aya Kobayashi,Hiroshi Okuda,Fei Xing,Puspa R. Pandey,Misako Watabe,Shigeru Hirota,Sudha K. Pai,Wen Liu,Koji Fukuda,Christopher B. Chambers,Andrew Wilber,Kounosuke Watabe +11 more
TL;DR: BMP7 released by bone marrow stromal cells induces reversible senescence of prostate cancer stem-like cells, and BMPR2 expression inversely correlates with bone metastasis and recurrence in prostate cancer patients.