H
Hakho Lee
Researcher at Harvard University
Publications - 192
Citations - 16590
Hakho Lee is an academic researcher from Harvard University. The author has contributed to research in topics: Magnetic nanoparticles & Nanoparticle. The author has an hindex of 56, co-authored 190 publications receiving 13130 citations. Previous affiliations of Hakho Lee include Yonsei University.
Papers
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Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor
Hyungsoon Im,Huilin Shao,Yong Il Park,Vanessa M. Peterson,Cesar M. Castro,Ralph Weissleder,Hakho Lee +6 more
TL;DR: The nano-plasmonic exosome (nPLEX) assay is based on transmission surface plasmon resonance through periodic nanohole arrays and offers improved sensitivity over previous methods, enables portable operation when integrated with miniaturized optics and allows retrieval of exosomes for further study.
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New Technologies for Analysis of Extracellular Vesicles
TL;DR: This article aims to present a comprehensive and critical overview of emerging analytical technologies for EV detection and their clinical applications.
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Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis
Sidi Chen,Sidi Chen,Neville E. Sanjana,Kaijie Zheng,Ophir Shalem,Kyungheon Lee,Xi Shi,David A. Scott,Jun S. Song,Jen Q. Pan,Ralph Weissleder,Hakho Lee,Feng Zhang,Phillip A. Sharp +13 more
TL;DR: In this paper, a genome-wide CRISPR/Cas9-mediated loss-of-function screen in tumor growth and metastasis was described. But the authors focused on the effect of mutations on primary tumor growth positively correlates with the development of metastases.
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Protein typing of circulating microvesicles allows real-time monitoring of glioblastoma therapy
Huilin Shao,Jaehoon Chung,Leonora Balaj,Alain Charest,Darell D. Bigner,Bob S. Carter,Fred H. Hochberg,Xandra O. Breakefield,Ralph Weissleder,Hakho Lee +9 more
TL;DR: It is shown that circulating GBM microvesicles can be used to analyze primary tumor mutations and as a predictive metric of treatment-induced changes and could provide both an early indicator of drug efficacy and a potential molecular stratifier for human clinical trials.
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Chip–NMR biosensor for detection and molecular analysis of cells
TL;DR: The capability of the DMR system is shown by using it to detect bacteria with high sensitivity, identify small numbers of cells and analyze them on a molecular level in real time, and measure a series of protein biomarkers in parallel.