다중혈관 관상동맥 환자에서 y-문합을 이용하여 양쪽 내흉동맥만을 사용한 우회술의 조기 성적

抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Transparent films of carbon nanotubes can accommodate strains of up to 150% and demonstrate conductivities as high as 2,200 S cm−1 in the stretched state.

Skin-like pressure and strain sensors based on transparent elastic films of carbon nanotubes

New technologies for imaging molecules, particularly optical technologies, are increasingly being used to understand the complexity, diversity and in vivo behaviour of cancers. 'Omic' approaches are providing comprehensive 'snapshots' of biological indicators, or biomarkers, of cancer, but imaging can take this information a step further, showing the activity of these markers in vivo and how their location changes over time. Advances in experimental and clinical imaging are likely to improve how cancer is understood at a systems level and, ultimately, should enable doctors not only to locate tumours but also to assess the activity of the biological processes within these tumours and to provide 'on the spot' treatment.

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Imaging in the era of molecular oncology

Human skin is a remarkable organ. It consists of an integrated, stretchable network of sensors that relay information about tactile and thermal stimuli to the brain, allowing us to maneuver within our environment safely and effectively. Interest in large-area networks of electronic devices inspired by human skin is motivated by the promise of creating autonomous intelligent robots and biomimetic prosthetics, among other applications. The development of electronic networks comprised of flexible, stretchable, and robust devices that are compatible with large-area implementation and integrated with multiple functionalities is a testament to the progress in developing an electronic skin (e-skin) akin to human skin. E-skins are already capable of providing augmented performance over their organic counterpart, both in superior spatial resolution and thermal sensitivity. They could be further improved through the incorporation of additional functionalities (e.g., chemical and biological sensing) and desired properties (e.g., biodegradability and self-powering). Continued rapid progress in this area is promising for the development of a fully integrated e-skin in the near future.

25th Anniversary Article: The Evolution of Electronic Skin (E-Skin): A Brief History, Design Considerations, and Recent Progress

Underlying physical mechanisms controlling the noise properties of oscillators are studied. This treatment shows the importance of inductance selection for oscillator noise optimization. A design strategy centered around an inductance selection scheme is executed using a practical graphical optimization method to optimize phase noise subject to design constraints such as power dissipation, tank amplitude, tuning range, startup condition, and diameters of spiral inductors. The optimization technique is demonstrated through a design example, leading to a 2.4-GHz fully integrated, LC voltage-controlled oscillator (VCO) implemented using 0.35-/spl mu/m MOS transistors. The measured phase-noise values are -121, -117, and -115 dBc/Hz at 600-kHz offset from 1.91, 2.03, and 2.60-GHz carriers, respectively. The VCO dissipates 4 mA from a 2.5-V supply voltage. The inversion mode MOSCAP tuning is used to achieve 26% of tuning range. Two figures of merit for performance comparison of various oscillators are introduced and used to compare this work to previously reported results.

/pdf/concepts-and-methods-in-optimization-of-integrated-lc-vcos-21e0f32gpk.pdf

Concepts and methods in optimization of integrated LC VCOs

Rapid and accurate measurement of biomarkers in tissue and fluid samples is a major challenge in medicine. Here we report the development of a new, miniaturized diagnostic magnetic resonance (DMR) system for multiplexed, quantitative and rapid analysis. By using magnetic particles as a proximity sensor to amplify molecular interactions, the handheld DMR system can perform measurements on unprocessed biological samples. We show the capability of the DMR system by using it to detect bacteria with high sensitivity, identify small numbers of cells and analyze them on a molecular level in real time, and measure a series of protein biomarkers in parallel. The DMR technology shows promise as a robust and portable diagnostic device.

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Chip–NMR biosensor for detection and molecular analysis of cells

www.MaterialsViews.com C O M Stretchable Microfl uidic Radiofrequency Antennas M U N I By Masahiro Kubo , Xiaofeng Li , Choongik Kim , Michinao Hashimoto , Benjamin J. Wiley , Donhee Ham , and George M. Whitesides * C A IO N This paper describes a new method for fabricating stretchable radiofrequency antennas. The antennas consist of liquid metal (eutectic gallium indium alloy, EGaIn [ 1 , 2 ] ) enclosed in elastomeric microfl uidic channels. In particular, a microfl uidic structure made of two types of elastomers (polydimethylsiloxane (PDMS) and Ecofl ex (type 0030, Reynolds Advanced Materials)) with different stiffness has been developed to improve the stretchability and mechanical stability of the antennas. These antennas can be stretched up to a strain [defi ned as the percentage change in length or ( l – l 0 )/ l 0 ] of 120 %. This high stretchability allows the resonance frequencies of the antennas to be mechanically tuned over a wide range of frequencies. The antennas can also be repeatedly stretched, while retaining a high effi ciency (> 95 %) in radiation. “Stretchability” in electronics has the potential to open new opportunities, particularly for large-area devices and systems, and in systems that require the device to conform to a nonplanar surface, or to bend and stretch while in use. [ 3–5 ] Compared to “fl exible” electronics built on nonstretchable polymer or paper substrates, [ 6 , 7 ] stretchable electronics can cover almost arbitrarily curved surfaces and movable parts. Mechanical compliance may increase the comfort of the user for wearable electronics or implantable medical devices, and simplify the integration for a range of applications. [ 3–5 , 8 ] New approaches to stretchable electronics are now being developed. In a recent advance, Rogers et al. [ 4 , 5 ] described stretchable integrated circuits with elongation of up to 100 % using wavy, thin silicon ribbons on pre-stretched elastic substrates. Antennas offer new, attractive applications for stretchable electronics; these applications might include reconfi gurable antennas, [ 9 ] antennas for limited and nonplanar spaces, [ 10 ] and wearable sensors. Two methods are commonly used to build antennas for commercial applications. The most common method uses sheet-metal processing; in this method, a metal sheet is punched, bent, and welded into the desired structure. A second method uses chemical etching and plating to make small patterns of metal. This method can make fl exible antennas by patterning metal on a fl exible substrate. Neither

/pdf/stretchable-microfluidic-radiofrequency-antennas-1c42d10mbp.pdf

Stretchable Microfluidic Radiofrequency Antennas

Inexpensive sophisticated circuitry can be ‘painted’ on to plastic or glass substrates. Macroelectronic circuits made on substrates of glass or plastic could one day make computing devices ubiquitous owing to their light weight, flexibility and low cost1. But these substrates deform at high temperatures so, until now, only semiconductors such as organics and amorphous silicon2 could be used, leading to poor performance. Here we present the use of low-temperature processes to integrate high-performance multi-nanowire transistors into logical inverters and fast ring oscillators on glass substrates. As well as potentially enabling powerful electronics to permeate all aspects of modern life, this advance could find application in devices such as low-cost radio-frequency tags and fully integrated high-refresh-rate displays.

/pdf/nanotechnology-high-speed-integrated-nanowire-circuits-3fef3jjq69.pdf

Nanotechnology: High-speed integrated nanowire circuits

Atomically thin two-dimensional (2D) materials-such as transition metal dichalcogenide (TMD) monolayers and hexagonal boron nitride (hBN)-and their van der Waals layered preparations have been actively researched to build electronic devices such as field-effect transistors, junction diodes, tunneling devices, and, more recently, memristors. Two-dimensional material memristors built in lateral form, with horizontal placement of electrodes and the 2D material layers, have provided an intriguing window into the motions of ions along the atomically thin layers. On the other hand, 2D material memristors built in vertical form with top and bottom electrodes sandwiching 2D material layers may provide opportunities to explore the extreme of the memristive performance with the atomic-scale interelectrode distance. In particular, they may help push the switching voltages to a lower limit, which is an important pursuit in memristor research in general, given their roles in neuromorphic computing. In fact, recently Akinwande et al. performed a pioneering work to demonstrate a vertical memristor that sandwiches a single MoS2 monolayer between two inert Au electrodes, but it could neither attain switching voltages below 1 V nor control the switching polarity, obtaining both unipolar and bipolar switching devices. Here, we report a vertical memristor that sandwiches two MoS2 monolayers between an active Cu top electrode and an inert Au bottom electrode. Cu ions diffuse through the MoS2 double layers to form atomic-scale filaments. The atomic-scale thickness, combined with the electrochemical metallization, lowers switching voltages down to 0.1-0.2 V, on par with the state of the art. Furthermore, our memristor achieves consistent bipolar and analogue switching, and thus exhibits the synapse-like learning behavior such as the spike-timing dependent plasticity (STDP), the very first STDP demonstration among all 2D-material-based vertical memristors. The demonstrated STDP with low switching voltages is promising not only for low-power neuromorphic computing, but also from the point of view that the voltage range approaches the biological action potentials, opening up a possibility for direct interfacing with mammalian neuronal networks.

Donhee Ham

Papers

Concepts and methods in optimization of integrated LC VCOs

Chip–NMR biosensor for detection and molecular analysis of cells

Stretchable Microfluidic Radiofrequency Antennas

Nanotechnology: High-speed integrated nanowire circuits

Vertical MoS2 Double-Layer Memristor with Electrochemical Metallization as an Atomic-Scale Synapse with Switching Thresholds Approaching 100 mV