Han Chen

TL;DR: A high-throughput screening assay for identifying small-molecule inhibitors of the eIF4E/eIF4G interaction identifies 4EGI-1, a new tool for studying translational control and establishes a possible new strategy for cancer therapy.

TL;DR: Structure-activity relationship studies of substituted arylsulfoanilides as antiproliferatives, which are mediated by the partial depletion of intracellular Ca(2+) stores, resulted in the identification of compounds with micromolar activity against lung cancer cells in a growth inhibition assay.

TL;DR: The diphenyloxindole showed mechanism-specific antiproliferative activity that was comparable to known translation initiation inhibitors such as clotrimazole or troglitazone and identified as a lead compound for Ca2+-depletion-mediated inhibition of translation initiation.

TL;DR: Several candidates of the 5-benzylidene-thiazolidine-2,4-diones inhibit cell growth with low microM GI(50) mediated by inhibition of translation initiation, which involves partial depletion of intracellular Ca(2+) stores and strong phosphorylation of eIF2alpha.

TL;DR: The findings on the minimum structural requirements for both compounds to retain their calcium release and antiproliferative activities are reported.