H
Han Lin
Researcher at Wenzhou Medical College
Publications - 43
Citations - 870
Han Lin is an academic researcher from Wenzhou Medical College. The author has contributed to research in topics: Leydig cell & Stem cell. The author has an hindex of 13, co-authored 35 publications receiving 677 citations. Previous affiliations of Han Lin include Rockefeller University.
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Journal ArticleDOI
Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero
Han Lin,Ren-Shan Ge,Guo-Rong Chen,Guo-Xin Hu,Lei Dong,Qingquan Lian,Dianne O. Hardy,Chantal M. Sottas,Li Xiaokun,Matthew P. Hardy +9 more
TL;DR: It is indicated that fetal exposures to DEHP have effects on FLC number, distribution, and most importantly, steroidogenic capacity and suggest that abnormal expressions of IGF1, KITL, and LIF genes may contribute to the reproductive toxicity of phthalates.
Journal ArticleDOI
Rapid mechanisms of glucocorticoid signaling in the Leydig cell.
Guo-Xin Hu,Qing-Quan Lian,Han Lin,Han Lin,Syed A. Latif,David J. Morris,Matthew P. Hardy,Ren-Shan Ge,Ren-Shan Ge +8 more
TL;DR: Under stress conditions, glucocorticoids have rapid actions to suppress cAMP formation thus to lower testosterone production and 17beta-hydroxysteroid dehydrogenase 3 forms the coupling with 11betaHSD1 which constitutes a rapid mechanism for modulating glucOCorticoid control of testosterone biosynthesis.
Journal ArticleDOI
Deletion of the Igf1 gene: suppressive effects on adult Leydig cell development.
Guo-Xin Hu,Han Lin,Guo Rong Chen,Bing Bing Chen,Qing Quan Lian,Dianne O. Hardy,Barry R. Zirkin,Ren Shan Ge,Ren Shan Ge +8 more
TL;DR: The reduced numbers of Leydig cells in the adult testes of Igf1(-/-) mice result at least in part from altered proliferation and differentiation of ALC precursor cells, but not of the stem cells that give rise to these cells.
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In Utero Exposure to Diethylhexyl Phthalate Affects Rat Brain Development: A Behavioral and Genomic Approach
TL;DR: The study demonstrated the changed gene expression patterns after in utero DEHP exposure might partially contribute to the deficit of cognitive function at adulthood.
Journal ArticleDOI
Curcumin as a potent and selective inhibitor of 11β-hydroxysteroid dehydrogenase 1: improving lipid profiles in high-fat-diet-treated rats.
Guo-Xin Hu,Han Lin,Qing-Quan Lian,Shu-Hua Zhou,Jingjing Guo,Hong-Yu Zhou,Yanhui Chu,Ren-Shan Ge,Ren-Shan Ge +8 more
TL;DR: Curcumin is effective for the treatment of metabolic syndrome and four novel curcumin derivatives had high potencies for inhibition of human 11 β-HSD1 with selectivity against 11β- HSD2.