L
Lei Dong
Researcher at Shanghai Jiao Tong University
Publications - 27
Citations - 1097
Lei Dong is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Leydig cell & Cancer. The author has an hindex of 12, co-authored 24 publications receiving 843 citations. Previous affiliations of Lei Dong include Wenzhou Medical College & Fudan University.
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Journal ArticleDOI
A Positive Feedback Loop of lncRNA-PVT1 and FOXM1 Facilitates Gastric Cancer Growth and Invasion.
Midie Xu,Yiqin Wang,Weiwei Weng,Ping Wei,Peng Qi,Qiongyan Zhang,Cong Tan,Shu Juan Ni,Lei Dong,Yusi Yang,Wanrun Lin,Qinghua Xu,Dan Huang,Zhaohui Huang,Yuqing Ma,Wei Zhang,Weiqi Sheng,Xiang Du +17 more
TL;DR: PVT1 may be a valuable prognostic predictor for gastric cancer, and the positive feedback loop of PVT1-FOXM1 could be a therapeutic target in pharmacologic strategies.
Journal ArticleDOI
Circulating Long RNAs in Serum Extracellular Vesicles: Their Characterization and Potential Application as Biomarkers for Diagnosis of Colorectal Cancer
Lei Dong,Wanrun Lin,Peng Qi,Midie Xu,Xiaoben Wu,Shujuan Ni,Dan Huang,Wei Wei Weng,Cong Tan,Weiqi Sheng,Xiaoyan Zhou,Xiang Du +11 more
TL;DR: Exosomal mRNAs and lncRNAs in serum could be used as biomarkers to detect colorectal cancer, and among three types of vesicles in sera, EXOs were the richest reservoir for almost all measured long RNAs.
Journal ArticleDOI
Circulating CUDR, LSINCT-5 and PTENP1 long noncoding RNAs in sera distinguish patients with gastric cancer from healthy controls
Lei Dong,Peng Qi,Midie Xu,Shu Juan Ni,Dan Huang,Qinghua Xu,Wei Wei Weng,Cong Tan,Wei Qi Sheng,Xiao Yan Zhou,Xiang Du +10 more
TL;DR: Three‐lncRNA signature in serum was identified as diagnostic marker for GC and may facilitate the detection of GC and serve as the basis for further studies of the clinical value of serum lncRNAs in maintaining surveillance and forecasting prognosis.
Journal ArticleDOI
Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero
Han Lin,Ren-Shan Ge,Guo-Rong Chen,Guo-Xin Hu,Lei Dong,Qingquan Lian,Dianne O. Hardy,Chantal M. Sottas,Li Xiaokun,Matthew P. Hardy +9 more
TL;DR: It is indicated that fetal exposures to DEHP have effects on FLC number, distribution, and most importantly, steroidogenic capacity and suggest that abnormal expressions of IGF1, KITL, and LIF genes may contribute to the reproductive toxicity of phthalates.
Posted ContentDOI
Single-Cell Map of Diverse Immune Phenotypes in the Metastatic Brain Tumor Microenvironment of Non Small Cell Lung Cancer
Liang Wang,Jinxiang Dai,Run-Run Han,Lei Dong,Dayun Feng,Gang Zhu,Wei Guo,Yuan Wang,Min Chao,Ming-Zhu Jin,Shi-Jia Jin,Dong-Ping Wei,Sun Wei,Weilin Jin +13 more
TL;DR: A unique alternative activation (M2) gene expression pattern of the TAM in the brain metastasis and a lack of known T cell co-stimulator expression are identified, which may cause the comprised anti-tumor T cell response in metastatic brain lesions.