https://cyberleninka.org/article/n/365946.pdf

The use of plants in the traditional management of diabetes in Nigeria: pharmacological and toxicological considerations.

Secondary metabolites from Ganoderma

Recent discovery of plant-derived anti-diabetic natural products

Bioactive benzofuran derivatives: moracins A-Z in medicinal chemistry.

In this study, leaves of three indigenous varieties of Mulberry namely, Morus alba L., Morus nigra L. and Morus rubra L. were investigated for their antioxidant potential and their proximate composition was determined. The yields of 80% methanolic extracts ranged between 8.28-13.89%. The contents of total phenolics (TPC), total flavonoids (TFC) and ascorbic acid (AA) ranged between 16.21-24.37 mg gallic acid equivalent (GAE)/g, 26.41-31.28 mg rutin equivalent (RE)/g and 0.97-1.49 mg/g, respectively. The antioxidant activity of leaf extracts was evaluated by measuring 1,1-diphenyl-2-picrylhydrazyl (DPPH(•)) radical scavenging actity, 2,2'-azino-bis-(3-ethylbenzthiazoline-6-sulphonic acid (ABTS(•+)) radical cation scavenging capacity and ferric ion reducing power and values ranged between 1.89-2.12, 6.12-9.89 and 0.56-0.97 mM Trolox equivalent/g of dried leaves, respectively. The investigated features reveal good nutritive and antioxidant attributes of all the varieties with mutually significant differences.

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Proximate Composition and Antioxidant Potential of Leaves from Three Varieties of Mulberry (Morus sp.): A Comparative Study

In vivo hypoglycemic effects of phenolics from the root bark of Morus alba.

A new indole alkaloid 1, together with four known indole alkaloids 2–5, was isolated from the 95% EtOH extract of the traditional Chinese medicinal plant Isatis indigotica. Alkaloids 2–5 were found in the plant for the first time. Their structures were elucidated as 3-hydroxy-3-acetonitrile-4-hydroxy-2-indolone (1), 1-methoxy-3-indoleacetonitrile (2), 3-indoleacetic acid (3), 3-indolealdehyde (4), and 1-methoxy-3indolecarbaldehyde (5) on the basis of spectroscopic data. Their anti-HSV effects in vitro were evaluated by plaque reduction assay.

Indole alkaloids from the roots of Isatis ingigotica and their antiherpes simplex virus type 2 (HSV-2) activity in vitro

New sphingolipids from the root of Isatis indigotica and their cytotoxic activity.

Two new ceramides were isolated from the 95% EtOH extract of traditional Chinese medicinal plant Isatis indigotica. Their structures were elucidated as 1-O-β-D-glucopyranosyl-(2S, 3R)-N-(2′-hydroxype-ntacosanoyl)-octadeca-11E-sphingenine (1) and 1-O-β-D-glucopyranosyl-(2S,3R)-N-(2′-hydroxyhe xacosanoyl)-octadeca-11E-sphingenine (2) on the basis of spectroscopic data. Their cytotoxic effects were evaluated by using MTT method.

Isolation, structural determination and cytotoxic activity of two new ceramides from the root of Isatis indigotica

In addition to two ceramides 1-O-β-D-glucopyranosyl-(2S,3R)-N-(2'-hydroxyhexadecanoyl)-octadeca-4E,8Esphingenine (2) and (2S,3S,4R)-N-(2'-hydroxytetracosanoyl)-octadecasphingenine (3), which separated for the first time, a new ceramide 1-O-β-D-glucopyranosyl-(2S,3R)-N-(2'-hydroxyhexacosanoyl)octadecasphingenine (1) was isolated from the traditional Chinese medicinal herb Isatis indigotica. Their cytotoxic effects were evaluated by the MTT method.

Han-Qing Zhang

Papers

In vivo hypoglycemic effects of phenolics from the root bark of Morus alba.

Indole alkaloids from the roots of Isatis ingigotica and their antiherpes simplex virus type 2 (HSV-2) activity in vitro

New sphingolipids from the root of Isatis indigotica and their cytotoxic activity.

Isolation, structural determination and cytotoxic activity of two new ceramides from the root of Isatis indigotica

A new ceramide from the root of Isatis Indigotica and its cytotoxic activity